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beta3-adrenergic receptor activity

Known as: beta3 adrenoceptor 
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological… 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
The first‐in‐man randomized trial of a beta3 adrenoceptor agonist in chronic heart failure: the BEAT‐HF trial
The third isotype of beta adrenergic receptors (β3 ARs) has distinctly different effects on cardiomyocytes compared with β1 and… 
2010
2010
The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin.
BACKGROUND & AIMS beta3 Adrenoceptor (beta3-AR) is expressed on adipocytes and enteric neurons. GW427353 is a human selective… 
Highly Cited
2008
Highly Cited
2008
Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2
Background The lactogenic hormones prolactin (PRL) and placental lactogens (PL) play central roles in reproduction and mammary… 
2008
2008
Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders.
The characterization of the first selective orally active and brain-penetrant beta3-adrenoceptor agonist, SR58611A (amibegron… 
Highly Cited
2007
Highly Cited
2007
Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?
Review
2007
Review
2007
Modeling and informatics in designing anti-diabetic agents.
Diabetes mellitus is a chronic metabolic disorder, characterized by glucose overproduction and glucose underutilization. Current… 
2006
2006
Association of polymorphisms in the beta2 and beta3 adrenoceptor gene with polycystic ovary syndrome.
OBJECTIVE To investigate polymorphisms of the beta2 and beta3 adrenoceptor (BAR-2 and BAR-3, respectively) genes associated with… 
2005
2005
Activation of β3 Adrenergic Receptor Decreases DNA synthesis in Human Skin Fibroblasts Via Cyclic GMP/Nitric Oxide Pathway
Background: Evidences have shown that β1 and β2 adrenoceptors co-exist in human fibroblasts, but it is not yet clear the… 
Highly Cited
2003
Highly Cited
2003
Involvement of the &bgr;3 Adrenoceptor in Nebivolol-Induced Vasorelaxation in the Rat Aorta
Nebivolol is a highly selective &bgr;1 adrenoceptor blocker with additional vasodilating properties. Although it has been shown… 
1998
1998
Site-directed mutagenesis of the human beta3-adrenoceptor--transmembrane residues involved in ligand binding and signal transduction.
All three subtypes of beta-adrenoceptors are coupled to stimulation of adenylyl cyclase activity via the stimulatory guanine… 
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