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The health implications of birth by Caesarean section
Since the first mention of fetal programming of adult health and disease, a plethora of programming events in early life has been suggested. These have included intrauterine and postnatal events, butExpand
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Maternal nutrition alters the expression of insulin-like growth factors in fetal sheep liver and skeletal muscle.
We investigated the influence of maternal dietary restriction between days 28 and 80 of gestation followed by re-feeding to the intake of well-fed ewes up to 140 days of gestation (term is 147 days)Expand
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Ontogeny and nutritional programming of adiposity in sheep: potential role of glucocorticoid action and uncoupling protein-2.
Increased glucocorticoid action and adipose tissue inflammation contribute to excess adiposity. These adaptations may be enhanced in offspring exposed to nutrient restriction (NR) in utero, therebyExpand
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Ontogeny and nutritional programming of uncoupling protein‐2 and glucocorticoid receptor mRNA in the ovine lung
This study investigated the developmental and nutritional programming of uncoupling protein‐2 (UCP2), glucocorticoid receptor (GR) and 11β‐hydroxysteroid dehydrogenase type 1 (11βHSD1) mRNA in theExpand
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Endocrine and nutritional regulation of fetal adipose tissue development.
In the fetus, adipose tIssue comprises both brown and white adipocytes for which brown fat is characterised as possessing the unique uncoupling protein (UCP)1. The dual characteristics of fetal fatExpand
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Animal models for the study of the developmental origins of health and disease.
Human epidemiological studies have indicated that the risk of developing non-communicable diseases in later life may be related to exposures during the developmental period. Developmental life is aExpand
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Influence of porcine genotype on the abundance of thyroid hormones and leptin in sow milk and its impact on growth, metabolism and expression of key adipose tissue genes in offspring.
Neonatal mortality is greater in commercial porcine genotypes, compared with the ancient Meishan breed that rapidly lay down adipose tissue; this may be related to hormones, such as triiodothyronineExpand
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Influence of genotype on the differential ontogeny of uncoupling protein 2 and 3 in subcutaneous adipose tissue and muscle in neonatal pigs.
The present study aimed to determine whether porcine genotype and/or postnatal age influenced mRNA abundance or protein expression of uncoupling protein (UCP)2 or 3 in subcutaneous adipose tissueExpand
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An exploration of student experiences of using biology podcasts in nursing training
BackgroundStudents regard biological science as one of the most difficult components of the nursing curriculum. However, a good understanding of this area is essential for effective nursing practice.Expand
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UCP1 is present in porcine adipose tissue and is responsive to postnatal leptin.
Intrauterine growth restriction (IUGR) may be accompanied by inadequate thermoregulation, especially in piglets that are not considered to possess any brown adipose tissue (BAT) and are thus entirelyExpand
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