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beta-chimaerin

Known as: beta 2-chimaerin, beta2-chimaerin 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

CHN2 protein, human

Broader (1)

Neoplasm Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
p23/Tmp21 Differentially Targets the Rac-GAP β2-Chimaerin and Protein Kinase C via Their C1 Domains
The ER/Golgi protein p23/Tmp21 acts as a C1 domain-docking protein that mediates perinuclear translocation of β-chimaerin. C1… 
2010
2010
A Novel Cross-talk in Diacylglycerol Signaling
Although the family of chimaerin Rac-GAPs has recently gained significant attention for their involvement in development, cancer… 
2009
2009
β2‐Chimaerin binds to EphA receptors and regulates cell migration
2009
2009
Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.
Recent studies established that the Rac-GAP beta2-chimaerin plays important roles in development, neuritogenesis, and cancer… 
2007
2007
β2-Chimaerin in Cancer Signaling: Connecting Cell Adhesion and MAP Kinase Activation
The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates β2-chimaerin in tumor… 
2007
2007
Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor.
Diacylglycerol kinase (DGK)gamma was shown to act as an upstream suppressor of Rac1. Here we report that, in COS7 cells… 
2006
2006
Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling.
Although receptor-mediated regulation of small G-proteins and the cytoskeleton is intensively studied, the mechanisms for… 
2005
2005
Role of β2-chimaerin in the behaviour of murine mammary carcinoma cells in response to extracellular matrix components
Chimaerins are high affinity receptors for phorbol esters and diacylglycerol (DAG), unrelated to the protein kinase C isozymes… 
2002
2002
Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation…
Anthracycline antibiotics like doxorubicin (DOX) are known to exert their antitumor effects primarily via DNA intercalation and… 
2001
2001
Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-delta.
N-Benzyladriamycin-14-valerate (AD 198) is a semisynthetic anthracycline with experimental antitumor activity superior to that of… 
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