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Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
TLDR
The main aim of this article is to review recent literature on TIMPs with special emphasis on their biological activities and the possibility that they may have paradoxical roles in tumor progression. Expand
Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.
TLDR
It is shown that the classical mitogenic pathway involving Ras-Erk, PKC-ErK or Rac-JNK, among others, is activated by growth factors or endogenously by oncogenes, and constitutively activates uPA and uPAR expression. Expand
Telomere structure and telomerase in health and disease
TLDR
This review focuses on the structure and function of the telomere/telomerase complex and its altered behavior leading to disease, mainly cancer. Expand
Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer.
TLDR
The data suggest that tumor cell migration and proteolysis may be associated with the antitumor and antiangiogenic activity of soy isoflavone genistein. Expand
NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines
TLDR
The present paper examines the role of NGc-gangliosides in tumor biology as well as the available preclinical and clinical data on these vaccine products and the relevance of prioritization of cancer antigens in vaccine development. Expand
T cells are crucial for the anti-metastatic effect of anti-epidermal growth factor receptor antibodies
TLDR
An in vivo role for T cell response in the mechanism of action of anti-EGFR mAbs is supported, suggesting the induction of an adjuvant effect. Expand
The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).
TLDR
The emerging understanding of the roles of PKC isozymes in the three sequential cellular processes of tumor invasion and metastasis is reviewed: attachment to extracellular matrix or basement membrane components, matrix degradation by proteolytic enzymes, and migration through the digested matrix. Expand
Characterization of F3II, a sarcomatoid mammary carcinoma cell line originated from a clonal subpopulation of a mouse adenocarcinoma
TLDR
The data suggest that F3II is less differentiated and more aggressive than the original tumor line, supporting the notion that mammary carcinomas are heterogeneous neoplasms and contain subpopulations with diverse biologic behavior. Expand
Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer
TLDR
The present study evidenced the expression of NeuGc-GM3 in a high proportion of neuroectodermal tumors, suggesting its potential utility as a specific target of immunotherapy. Expand
Racotumomab for treating lung cancer and pediatric refractory malignancies
TLDR
In a recent phase I clinical trial in children with relapsed or resistant neuroectodermal malignancies, racotumomab was well tolerated and immunogenic, and its evaluation as immunotherapy for high-risk neuroblastoma is warranted. Expand
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