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Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
TLDR
The main aim of this article is to review recent literature on TIMPs with special emphasis on their biological activities and the possibility that they may have paradoxical roles in tumor progression. Expand
Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.
TLDR
It is shown that the classical mitogenic pathway involving Ras-Erk, PKC-ErK or Rac-JNK, among others, is activated by growth factors or endogenously by oncogenes, and constitutively activates uPA and uPAR expression. Expand
Tissue inhibitor of metalloproteinases‐1 promotes liver fibrosis development in a transgenic mouse model
TLDR
Transgenic mice overexpressing human TIMP‐1 in the liver under control of the albumin promoter/enhancer suggest that TIMP•1 does not by itself result in liver fibrosis, but strongly promotes Liver fibrosis development. Expand
Telomere structure and telomerase in health and disease
TLDR
This review focuses on the structure and function of the telomere/telomerase complex and its altered behavior leading to disease, mainly cancer. Expand
Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer.
TLDR
The data suggest that tumor cell migration and proteolysis may be associated with the antitumor and antiangiogenic activity of soy isoflavone genistein. Expand
NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines
TLDR
The present paper examines the role of NGc-gangliosides in tumor biology as well as the available preclinical and clinical data on these vaccine products and the relevance of prioritization of cancer antigens in vaccine development. Expand
The copper‐chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells
TLDR
Trientine dihydrochloride (trientine) is used in clinical practice as an alternative copper (Cu)‐chelating agent for patients with Wilson's disease of penicillamine intolerance and may be an effective new strategy for future HCC therapy. Expand
Mammary carcinoma cells over‐expressing tissue inhibitor of metalloproteinases‐1show vascular endothelial growth factor expression
TLDR
The findings suggest that over‐expression of TIMP‐1 confers growth advantage on breast carcinoma cells in vivo and that up‐regulation of VEGF expression may play an important role in this TIMP•1‐mediated, growth‐stimulating effect. Expand
The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).
TLDR
The emerging understanding of the roles of PKC isozymes in the three sequential cellular processes of tumor invasion and metastasis is reviewed: attachment to extracellular matrix or basement membrane components, matrix degradation by proteolytic enzymes, and migration through the digested matrix. Expand
Mammary carcinoma cells over-expressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression.
TLDR
The findings suggest that over-expression of TIMP-1 confers growth advantage on breast carcinoma cells in vivo and that up-regulation of VEGF expression may play an important role in this TIMP1-1-mediated, growth-stimulating effect. Expand
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