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benzyloxycarbonyl-Phe-Ala-fluormethylketone

Known as: ZFA-fmk, Z-Phe-AlaCH2F, carbobenzoxy-L-phenylalanyl-(D,L)-alanyl fluoromethyl ketone 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Gingipains from Porphyromonas gingivalis W83 Synergistically Disrupt Endothelial Cell Adhesion and Can Induce Caspase-Independent Apoptosis
ABSTRACT We have shown previously that gingipains from Porphyromonas gingivalis W83 can induce cell detachment, cell adhesion… 
Highly Cited
2004
Highly Cited
2004
Human Malignant Glioma Therapy Using Anti-αVβ3 Integrin Agents
Glioblastoma multiforme (GBM) is the most frequent malignant brain tumor in adults and is invariably fatal. We have investigated… 
Highly Cited
2004
Highly Cited
2004
Caspase-3 Inhibitor Prevents Apoptosis of Human Islets Immediately After Isolation and Improves Islet Graft Function
Objectives: Apoptosis appears in islets after isolation, and it has a detrimental effect on the islet function. To improve the… 
Highly Cited
2002
Highly Cited
2002
Cyclosporine a protects against arachidonic acid toxicity in rat hepatocytes: Role of CYP2E1 and mitochondria
Diets high in polyunsaturated fatty acids (PUFA) are important for the development of alcoholic liver injury. The goal of this… 
Highly Cited
2000
Highly Cited
2000
Cadmium induces caspase-mediated cell death: suppression by Bcl-2.
Highly Cited
1999
Highly Cited
1999
Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C.
Activation of caspases is critical for the induction of apoptosis. We have shown previously that cell death mediated by the… 
Highly Cited
1999
Highly Cited
1999
Caspase involvement in the induction of apoptosis by the environmental toxicants tributyltin and triphenyltin.
Organotin compounds such as tributyltin (TBT) and triphenyltin (TPT) can kill target cells by triggering apoptosis. The mechanism… 
Highly Cited
1998
Highly Cited
1998
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide
Highly Cited
1998
Highly Cited
1998
Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia
In rats, striatal histotoxic hypoxic lesions produced by the mitochondrial toxin malonate resemble those of focal cerebral… 
Highly Cited
1997
Highly Cited
1997
Activation of PKCα Downstream from Caspases during Apoptosis Induced by 7-Hydroxystaurosporine or the Topoisomerase Inhibitors, Camptothecin and Etoposide, in Human Myeloid Leukemia HL60 Cells*
We previously demonstrated that the anticancer agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces… 
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