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benzyloxycarbonyl-Phe-Ala-fluormethylketone

Known as: ZFA-fmk, Z-Phe-AlaCH2F, carbobenzoxy-L-phenylalanyl-(D,L)-alanyl fluoromethyl ketone 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells.
Anthraquinone compounds have been shown to induce apoptosis in different cancer cell types. Effects of chrysophanol, an… 
Highly Cited
2005
Highly Cited
2005
Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26.
The inhibition of the caspase-3 enzyme is reported to increase neuronal cell survival following cerebral ischemia. The peptide Z… 
Highly Cited
2005
Highly Cited
2005
Fucoidan induces apoptosis of human HS‐Sultan cells accompanied by activation of caspase‐3 and down‐regulation of ERK Pathways
Fucoidan, a sulfated polysaccharide in brown seaweed, was found to inhibit proliferation and induce apoptosis in human lymphoma… 
Highly Cited
2004
Highly Cited
2004
N-Terminal Fragment of c-FLIP(L) Processed by Caspase 8 Specifically Interacts with TRAF2 and Induces Activation of the NF-κB Signaling Pathway
ABSTRACT Caspase 8 is required not only for death receptor-mediated apoptosis but also for lymphocyte activation in the immune… 
Highly Cited
2002
Highly Cited
2002
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells
The intracellular pathways leading to mitochondrial activation and subsequent cell death in the ceramide-mediated stress response… 
Highly Cited
2000
Highly Cited
2000
Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor.
Angiotensin-converting enzyme is involved in apoptosis of alveolar epithelial cells (Wang R, Zagariya A, Ang E, Ibarra-Sunga O… 
Highly Cited
1999
Highly Cited
1999
The Endoplasmic Reticulum Stress-Responsive Protein GRP78 Protects Neurons Against Excitotoxicity and Apoptosis: Suppression of Oxidative Stress and Stabilization of Calcium Homeostasis
The 78-kDa glucose-regulated protein (GRP78) is localized in the endoplasmic reticulum (ER), and its expression is increased by… 
Highly Cited
1999
Highly Cited
1999
Caspases Induce Cytochrome c Release from Mitochondria by Activating Cytosolic Factors*
We investigated the ability of caspases (cysteine proteases with aspartic acid specificity) to induce cytochromec release from… 
Highly Cited
1999
Highly Cited
1999
The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin*
In this study, we elucidate signaling pathways induced by photodynamic therapy (PDT) with hypericin. We show that PDT rapidly… 
Highly Cited
1998
Highly Cited
1998
Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia
Delayed neuronal death after transient cerebral ischemia may be mediated, in part, by the induction of apoptosis-regulatory gene… 
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