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benzonidazole

Known as: N-benzyl-2-nitro-1-imidazoleacetamide, BENZNIDAZOLE, N-benzyl-2-nitroimidazole-1-acetamide 
A nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Immunosuppressive AgentsMutagensNitroimidazolesTrypanocidal Agents

Narrower (1)

Radanil
benznidazole/lomustine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of Chagas disease.
The in vivo trypanosomicidal activity of the imidazole-based benzo[g]phthalazine derivatives 1-4 and of the new related pyrazole… 
Highly Cited
2011
Highly Cited
2011
The use of solid dispersion systems in hydrophilic carriers to increase benzonidazole solubility.
The present study investigates the release mechanism of benznidazole (BNZ) in solid dispersions with polyethylene glycol 6000… 
2001
2001
Cyclic voltammetric studies on nitro radical anion formation from megazol and some related nitroimidazole derivatives
2001
2001
Epitope Mapping of trans-Sialidase fromTrypanosoma cruzi Reveals the Presence of Several Cross-Reactive Determinants
ABSTRACT Trypanosoma cruzi, the agent of Chagas' disease, expresses trans-sialidase, a unique enzyme activity that enables the… 
2001
2001
Trypanocidal Drug Benznidazole Impairs Lipopolysaccharide Induction of Macrophage Nitric Oxide Synthase Gene Transcription Through Inhibition of NF-κB Activation1
In murine macrophages, inducible NO synthase II (NOSII) gene expression is promoted at a transcriptional level by LPS and/or IFN… 
Review
1999
Review
1999
Parasitological cure of Chagas disease: is it possible? Is it relevant?
Nearly 90 million people (about a quarter ofthe Latin American population) live in zones whereChagas disease is endemic while 18… 
Highly Cited
1999
Highly Cited
1999
QUIMIOTERAPIA DE LA ENFERMEDAD DE CHAGAS
1983
1983
Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
The ability of three nitroimidazoles [SR-2508, misonidazole (MISO), and benznidazole] with differing octanol-water partition… 
1983
1983
Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation.
Highly Cited
1982
Highly Cited
1982
Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations.
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