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benfluorex

Known as: Benfluorexum, 1-(3-trifluoromethylphenyl)-2-[N-(2-benzoyloxyethyl)amino]propane, benfluramate 
An antilipidemic agent that decreases the relative rate of hepatic triacylglycerol synthesis. Benfluorex was never approved for use in the United… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Appetite DepressantsFenfluramineHypolipidemic Agents

Narrower (2)

SE 780benfluorex hydrochloride
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Valvular heart disease associated with benfluorex therapy : results from the French multicentre registry
Department of Cardiology, University Hospital Brest, Brest, France; Department of Cardiology, University Hospital Amiens, Amiens… 
1993
1993
Effects of Benfluorex on Insulin Resistance and Lipid Metabolism in Obese Type II Diabetic Patients
OBJECTIVE To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with… 
1993
1993
Mechanism(s) of the blood glucose lowering action of benfluorex.
Benfluorex is a hypolipidaemic agent with biguanide-like properties. To evaluate its blood glucose lowering action, a single… 
1989
1989
Effects of benfluorex on glucose tolerance, metabolic control, beta-cell secretion, and peripheral sensitivity to insulin in obese type II diabetic patients on a body weight-maintaining diet
L'administration de benfluorex pendant 3 mois chez des diabetiques (type II) soumis a un regime alimentaire permettant de… 
1989
1989
Benfluorex action on metabolic control and insulin sensitivity in type 2 non-insulin dependent diabetics.
In this study, 16 overweight or obese NIDDM patients with a long period of stable weight and dietary surveillance were treated… 
1986
1986
Effects of benfluorex on sterol biosynthesis in incubated human blood mononuclear cells.
The hypocholesterolaemic drug Benfluorex has been shown to inhibit the rate of sterol synthesis in rat hepatocytes. At present no… 
1978
1978
Tolerance and cross tolerance to the anorexigenic effect of appetite suppressants in rats.
Rats were treated chronically with various anorexigenic substances which were administered orally once (or twice) daily or… 
1977
1977
The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue.
Rats were treated for 5 days with benfluorex [1-(3-trifluoromethylphenyl)-2-[N-(2-benzoyloxyethyl)amino]propane] or with… 
Highly Cited
1975
Highly Cited
1975
Drugs affecting the synthesis of glycerides and phospholipids in rat liver. The effects of clofibrate, halofenate, fenfluramine, amphetamine, cinchocaine, chlorpromazine, demethylimipramine…
The effects on glycerolipid synthesis of a series of compounds including many drugs were investigated in cell-free preparations… 
1973
1973
The tritium isotope effect of sn-glycerol 3-phosphate oxidase and the effects of clofenapate and N-(2-benzoyloxyethyl)norfenfluramine on the esterification of glycerol phosphate and dihydroxyacetone…
1. Owing to a (3)H isotope effect, the mitochondrial sn-glycerol 3-phosphate oxidase (EC 1.1.99.5) had a mean activity which was…