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benfluorex

Known as: Benfluorexum, 1-(3-trifluoromethylphenyl)-2-[N-(2-benzoyloxyethyl)amino]propane, benfluramate 
An antilipidemic agent that decreases the relative rate of hepatic triacylglycerol synthesis. Benfluorex was never approved for use in the United… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Appetite DepressantsFenfluramineHypolipidemic Agents

Narrower (2)

SE 780benfluorex hydrochloride
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Analysis of patients' narratives posted on social media websites on benfluorex's (Mediator®) withdrawal in France
Websites and discussion lists on health issues are among the most popular resources on the Web. Use experience reported on social… 
Review
2013
Review
2013
Drugs induced pulmonary arterial hypertension.
2010
2010
Valvular heart disease associated with benfluorex therapy : results from the French multicentre registry
Department of Cardiology, University Hospital Brest, Brest, France; Department of Cardiology, University Hospital Amiens, Amiens… 
2003
2003
Six-month efficacy of benfluorex vs. placebo or metformin in diet-failed type 2 diabetic patients
Abstract. Six-month efficacy of benfluorex (Mediator) (150–450 mg/day) was assessed in a double-blind multicenter study vs… 
2002
2002
Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression.
The effects of benfluorex and two of its metabolites (S 422-1 and S 1475-1) on fatty acid and glucose metabolic fluxes and… 
Highly Cited
1995
Highly Cited
1995
Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men.
To determine whether a reduction in insulinemia would be associated with a rise in serum dehydroepiandrosterone (DHEA) sulfate in… 
1993
1993
Effects of Benfluorex on Insulin Resistance and Lipid Metabolism in Obese Type II Diabetic Patients
OBJECTIVE To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with… 
1980
1980
Factors controlling the metabolism of phosphatidate by phosphohydrolase and phospholipase A-type activities. Effects of magnesium, calcium and amphiphilic cationic drugs.
1977
1977
The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue.
Rats were treated for 5 days with benfluorex [1-(3-trifluoromethylphenyl)-2-[N-(2-benzoyloxyethyl)amino]propane] or with… 
Highly Cited
1975
Highly Cited
1975
Drugs affecting the synthesis of glycerides and phospholipids in rat liver. The effects of clofibrate, halofenate, fenfluramine, amphetamine, cinchocaine, chlorpromazine, demethylimipramine…
The effects on glycerolipid synthesis of a series of compounds including many drugs were investigated in cell-free preparations… 
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