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beloranib

Known as: CKD-732, CKD732 
A fumagillin analogue and inhibitor of methionine aminopeptidase 2 (METAP2), with potential antiangiogenic and anti-obesity activity. As an… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (5)

CinnamatesCyclohexanesEpoxy CompoundsO-(4-dimethylaminoethoxycinnamoyl)fumagillol

Papers overview

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Review
2015
Review
2015
Aspergillus, angiogenesis, and obesity: the story behind beloranib.
Fumagillin, an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatus, four decades later was… 
2015
2015
Beloranib for prader-willi syndrome
2014
2014
Beloranib hemioxalate. Methionine aminopeptidase 2 inhibitor, Treatment of obesity
2010
2010
A phase Ib pharmacokinetic (PK) study of CKD-732 plus capecitabine and oxaliplatin (XELOX) in patients with metastatic colorectal cancer (mCRC) treated with prior irinotecan-based chemotherapy.
e13567 Background: CKD 732 is an antiangiogenic agent 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol hemioxalate. Since CKD-732… 
2009
2009
Angiogenesis inhibitor attenuates parathyroid hormone-induced anabolic effect.
2008
2008
CKD-732, a novel angiogenesis inhibitor: Evaluation of antitumor effect in vivo and preclinical studies in combination with oxaliplatin and capecitabine in colorectal cancer
LB-96 CKD-732 [6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol hemioxalate], a novel fumagillin derivative, showed a comparable… 
2005
2005
Central anorexic effect of TNP-470 analog (CKD-732) on fuel homeostasis
2004
2004
Development of parenteral formulation for a novel angiogenesis inhibitor, CKD-732 through complexation with hydroxypropyl-beta-cyclodextrin.
2004
2004
Antiangiogenic Anticancer Agent, CKD-732
2002
2002
The identification of in vitro metabolites of CKD-732 by liquid chromatography/tandem mass spectrometry.
The structural elucidation of fourteen metabolites of CKD-732, formed in vitro with rat liver microsomes, was performed using… 
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