azaphenylalanine

Serine proteases have proven to be promising pharmacological targets in contemporary drug discovery for cancer treatment. Since… (More)

Molecules regulating cell death constitute prominent therapeutic targets. The pro-apoptotic role of serine protease inhibitors… (More)

The conformational preferences of azaphenylalanine-containing peptide were investigated using a model compound, Ac-azaPhe-NHMe… (More)

Design, synthesis and biochemical evaluation of a series of novel non-covalent thrombin inhibitors with a 1-amidinopiperidine… (More)

The main structural feature of direct thrombin inhibitor LK-732 responsible for the appropriate interaction at the thrombin… (More)

The antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold (LK-732, LK-639 and LK-731… (More)

A series of azaphenylalanine derivatives were investigated as novel thrombin inhibitors based on the prodrug principle. By… (More)

Design, synthesis and biological evaluation of a series of novel non-covalent azaphenylalanine thrombin inhibitors are presented… (More)

New inhibitors of serine proteases with azaphenylalanine scaffold were synthesized and their activity was evaluated in vitro. We… (More)

In this paper the synthesis and antithrombotic activity of a series of novel thrombin inhibitors with azaphenylalanine scaffold… (More)