azaphenylalanine

Novel N-(N-Pg-azadipeptidoyl)benzotriazoles 20a-e couple efficiently with α-amino acids 21a-e, dipeptides 22a-c, aminoxyacetic… Expand

Serine proteases have proven to be promising pharmacological targets in contemporary drug discovery for cancer treatment. Since… Expand

Molecules regulating cell death constitute prominent therapeutic targets. The pro-apoptotic role of serine protease inhibitors… Expand

The conformational preferences of azaphenylalanine-containing peptide were investigated using a model compound, Ac-azaPhe-NHMe… Expand

The main structural feature of direct thrombin inhibitor LK-732 responsible for the appropriate interaction at the thrombin… Expand

The antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold (LK-732, LK-639 and LK-731… Expand

A series of azaphenylalanine derivatives were investigated as novel thrombin inhibitors based on the prodrug principle. By… Expand

New inhibitors of serine proteases with azaphenylalanine scaffold were synthesized and their activity was evaluated in vitro. We… Expand

Design, synthesis and biological evaluation of a series of novel non-covalent azaphenylalanine thrombin inhibitors are presented… Expand

Analogues of luliberin containing an alpha-azaamino acid in position 6, 9, or 10 (I--XIV) have been synthesized by the solution… Expand