atpenin A5

Known as: 3-(5,6-dichloro-2,4-dimethyl-hexanoyl)-2-hydroxy-5,6-dimethoxy-1H-pyridin-4-one 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2016
01220062016

Papers overview

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2017
2017
Mitochondrial complex II (CII) is an emerging target for numerous human diseases. Sixteen analogues of the CII inhibitor natural… (More)
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2016
2016
Asymmetric synthesis and initial biological studies of two analogues of a naturally occurring chlorinated antifungal agent… (More)
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2016
2016
Here, we report that choline and dimethylglycine can stimulate reactive oxygen species (ROS) production in liver mitochondria… (More)
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2014
2014
Dehydrogenases that use ubiquinone as an electron acceptor, including complex I of the respiratory chain, complex II, and… (More)
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2013
2013
The impact of complex II (succinate:ubiquinone oxidoreductase) on the mitochondrial production of reactive oxygen species (ROS… (More)
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Highly Cited
2012
Highly Cited
2012
Respiratory complex II oxidizes succinate to fumarate as part of the Krebs cycle and reduces ubiquinone in the electron transport… (More)
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2010
2010
Atpenins and harzianopyridone represent a unique class of penta-substituted pyridine-based natural products that are potent… (More)
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2009
2009
The cardioprotective effects of ischemic preconditioning (IPC) can be mimicked or blocked by pharmacologic agents, which modulate… (More)
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2009
2009
Enantioselective total synthesis of atpenin A5, a potent mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor… (More)
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2006
2006
The transfer of electrons and protons between membrane-bound respiratory complexes is facilitated by lipid-soluble redox-active… (More)
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