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Architecture of the Photosynthetic Oxygen-Evolving Center
The data strongly suggest that the OEC contains a cubane-like Mn3CaO4 cluster linked to a fourth Mn by a mono-μ-oxo bridge, and the details of the surrounding coordination sphere of the metal cluster and the implications for a possible oxygen-evolving mechanism are discussed.
Structure and Mechanism of the Lactose Permease of Escherichia coli
The crystal structure at 3.5 angstroms of the Escherichia coli lactose permease reveals the sugar-binding site in the cavity, and residues that play major roles in substrate recognition and proton translocation are identified.
Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans
The crystal structure at 2.8 Å resolution of the four protein subunits containing cytochrome c oxidase from the soil bacterium Paracoccus denitrificans, complexed with an antibody Fv fragment, is described and mechanisms for proton pumping are discussed.
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex.
Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme, and the "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme.
Structure of the human histamine H1 receptor complex with doxepin
Light is shed on the molecular basis of H1R antagonist specificity against H1r, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules.
The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides.
Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation
The structure of Escherichia colisuccinate dehydrogenase (SQR), analogous to the mitochondrial respiratory complex II, has been determined, revealing the electron transport pathway from the electron…
Molecular Basis of Proton Motive Force Generation: Structure of Formate Dehydrogenase-N
The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a major component of Escherichia coli nitrate respiration, has been determined and provides critical insights into the proton motive force generation by redox loop, a common mechanism among a wide range of respiratory enzymes.
G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
The raising of a mouse monoclonal antibody against human A2AAR that prevents agonist but not antagonist binding to the extracellular ligand-binding pocket is reported and results suggest a new strategy to modulate the activity of G-protein-coupled receptors.
Crystal structure of a prokaryotic homologue of the mammalian oligopeptide–proton symporters, PepT1 and PepT2
The crystal structure of PepTSo is presented, a functionally similar prokaryotic homologue of the mammalian peptide transporters from Shewanella oneidensis, which reveals a ligand‐bound occluded state for the MFS and provides new insights into a general transport mechanism.