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atorvastatin

Known as: (betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid, (betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-pyrrole-1-heptanoic Acid 
A synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which… 
National Institutes of Health

Related topics

Related topics

36 relations
Amlodipine / atorvastatinAmlodipine 5 MG / atorvastatin 80 MG Oral Tablet [Caduet]Atorvastatin SodiumAtorvastatin calcium

Broader (2)

Anticholesteremic AgentsPyrroles

Narrower (6)

CI 981CaduetLipitorLiptruzet

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections
Endogenous mechanisms leading to host protection and resolution of infections without immunosuppression are of wide interest… 
Highly Cited
2008
Highly Cited
2008
The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk…
Highly Cited
2007
Highly Cited
2007
Effect of OATP1B Transporter Inhibition on the Pharmacokinetics of Atorvastatin in Healthy Volunteers
The inhibition of hepatic uptake transporters, such as OATP1B1, on the pharmacokinetics of atorvastatin is unknown. Here, we… 
Highly Cited
2006
Highly Cited
2006
Role of Human Valve Interstitial Cells in Valve Calcification and Their Response to Atorvastatin
Background— Calcific aortic valve stenosis is a common disease in the elderly and is characterized by progressive calcification… 
Review
2006
Review
2006
The role of statins in cancer therapy.
Administration of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, to ambulatory patients is associated… 
Highly Cited
2005
Highly Cited
2005
Atorvastatin Inhibits Hypercholesterolemia-Induced Calcification in the Aortic Valves via the Lrp5 Receptor Pathway
Background—Calcific aortic valve disease is the most common indication for surgical valve replacement in the United States. The… 
Highly Cited
2003
Highly Cited
2003
The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin.
The prodrug clopidogrel (Plavix) is activated by cytochrome p450 (p450) to a metabolite that inhibits ADP-induced platelet… 
Review
1998
Review
1998
Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?
Highly Cited
1997
Highly Cited
1997
Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types.
Highly Cited
1996
Highly Cited
1996
Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia.
OBJECTIVE To assess the lipid-lowering effect of atorvastatin (a new 3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase… 
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