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Pathophysiology, Clinical Manifestations, and Prevention of Ischemia-Reperfusion Injury
Ischemia–reperfusion associated with thrombolytic therapy, organ transplantation, coronary angioplasty, aortic cross-clamping, or cardiopulmonary bypass results in local and systemic inflammation. Expand
Vascular ischaemia and reperfusion injury.
Although restoration of blood flow to an ischaemic organ is essential to prevent irreversible tissue injury, reperfusion per se may result in a local and systemic inflammatory response that mayExpand
The role of statins in cancer therapy.
Increasing clinical evidence suggests that statins, independent of their effects on serum cholesterol levels, may also play a potential role in the prevention and treatment of cancer. Expand
Neutrophil-derived Glutamate Regulates Vascular Endothelial Barrier Function*
It is concluded that activated human PMNs release glutamate and that endothelial expression of group I or III mGluRs function to decrease human brain endothelial VASP phosphorylation and barrier function. Expand
The Safety of Intraoperative Transesophageal Echocardiography: A Case Series of 7200 Cardiac Surgical Patients
The overall incidences of TEE-associated morbidity and mortality in the study population were 0.2% and 0%, respectively, and suggest that intraoperative TEE is a relatively safe diagnostic monitor for the management of cardiac surgical patients. Expand
Clopidogrel and bleeding in patients undergoing elective coronary artery bypass grafting.
Preheparin testing of platelet function with adenosine diphosphate aggregometry can identify patients at highest risk for perioperative bleeding and transfusions and might further reduce theperioperative transfusion requirement. Expand
Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1.
Investigation of whether oxidative stress increases human umbilical vein endothelial cell cytokeratin 1 (CK1) expression and activates the lectin complement pathway and whether MBL binding to endothelial cytokeratins may mediate LCP activation after oxidative stress suggests that MBLbinding to endothelium may Mediate L CP activation after antioxidant stress. Expand
Pharmacology and biological efficacy of a recombinant, humanized, single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass.
C5 inhibition significantly attenuates postoperative myocardial injury, cognitive deficits, and blood loss and suggests that C5 inhibition may represent a novel therapeutic strategy for preventing complement-mediated inflammation and tissue injury. Expand
Plasma Neutrophil Gelatinase-Associated Lipocalin and Acute Postoperative Kidney Injury in Adult Cardiac Surgical Patients
An early increase of post-CPB plasma NGAL is associated with AKI in adult patients undergoing CABG surgery, although the sensitivity is low, and assessing early Plasma NGAL alone has limited utility for predicting AKI. Expand
Hypoxia-induced expression of complement receptor type 1 (CR1, CD35) in human vascular endothelial cells.
Hypoxic HUVECs bound immune complexes and acted as a cofactor for factor I-mediated cleavage of C3b, and hypoxia induces functional HUV EC CR1 expression, which results in increased CD35 mRNA. Expand