ataluren

Known as: EC-000.2051 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2017
051020092017

Papers overview

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2016
2016
Alleles causing diseases that carry premature termination codons (PTCs) will cause premature cessation of translation, leading to… (More)
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2016
2016
A premature termination codon (PTC) in the ORF of an mRNA generally leads to production of a truncated polypeptide, accelerated… (More)
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Highly Cited
2014
Highly Cited
2014
INTRODUCTION Dystrophinopathy is a rare, severe muscle disorder, and nonsense mutations are found in 13% of cases. Ataluren was… (More)
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2014
2014
BACKGROUND Ataluren was developed to restore functional protein production in genetic disorders caused by nonsense mutations… (More)
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2013
2013
BACKGROUND Approximately 13% of boys with Duchenne muscular dystrophy (DMD) have a nonsense mutation in the dystrophin gene… (More)
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2013
2013
Heritable pulmonary arterial hypertension (HPAH) is a serious lung vascular disease caused by heterozygous mutations in the bone… (More)
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2013
2013
The drug molecule PTC124 (Ataluren) has been described as a read-through agent, capable of suppressing premature termination… (More)
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2011
2011
In a subset of patients with cystic fibrosis (CF), nonsense mutations (premature stop codons) disrupt production of full-length… (More)
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Highly Cited
2010
Highly Cited
2010
RATIONALE Nonsense (premature stop codon) mutations in mRNA for the cystic fibrosis transmembrane conductance regulator (CFTR… (More)
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2009
2009
Auld et al. (1) suggest that PTC124’s nonsense suppression activity may be an indirect consequence of the compound’s effects on… (More)
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