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asoxime chloride

Known as: HI 6, 1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane, H16 
National Institutes of Health

Related topics

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4 relations

Broader (4)

AntidoteCholinesterase ReactivatorsOximesPyridinium Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Highly Cited
2000
Highly Cited
2000
Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis.
Organophosphates inactivate acetylcholinesterase by reacting covalently with the active center serine. We have examined the… 
Highly Cited
1998
Highly Cited
1998
Neural lesions in the rat and their relationship to EEG delta activity following seizures induced by the nerve agent soman.
This study describes the neural structures damaged following exposure to the nerve agent soman, shows there are time-dependent… 
Highly Cited
1995
Highly Cited
1995
Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats.
Highly Cited
1992
Highly Cited
1992
Comparison of several oximes against poisoning by soman, tabun and GF.
Highly Cited
1992
Highly Cited
1992
Urinary excretion of diethylphosphorus metabolites in persons poisoned by quinalphos or chlorpyrifos
The urinary excretion rates of diethyl phosphate and diethyl phosphorothioate and changes in blood cholinesterase activities were… 
Highly Cited
1984
Highly Cited
1984
Isolation, anticholinesterase properties, and acute toxicity in mice of the four stereoisomers of the nerve agent soman.
Highly Cited
1982
Highly Cited
1982
HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat.
Highly Cited
1980
Highly Cited
1980
Reactivation of acetylcholinesterase inhibited by 1,2,2'-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes.
Highly Cited
1979
Highly Cited
1979
Ganglion blocking properties of some bispyridinium soman antagonists.
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