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asoxime chloride

Known as: HI 6, 1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane, H16 
National Institutes of Health

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Broader (4)

AntidoteCholinesterase ReactivatorsOximesPyridinium Compounds

Papers overview

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2009
2009
Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes
The toxicity of a combination of isopropyl methylphosphonofluoridate (sarin; GB) and cyclohexyl methylphosphonofluoridate (GF… 
2007
2007
Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats
The oximes HI-6, HLö-7, HGG-12, HGG-42 and obidoxime were used in a previously developed rat model to evaluate the therapeutic… 
2006
2006
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice
The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was… 
2005
2005
Distribution of the bispyridinium oxime [14C] HI-6 in male and female rats
Female rats poisoned with multiple LD50s of soman or tabun have been shown previously to respond to the protective effects of HI… 
2004
2004
MANAGEMENT OF CONVULSIONS IN NERVE AGENT ACUTE POISONING: A POLISH PERSPECTIVE
Symptoms of acute poisoning with nerve agents such as organophosphorus (OP) compounds include general convulsions that could lead… 
1990
1990
Oral forms of the oxime HI-6: a study of pharmacokinetics and tolerance after administration to healthy volunteers.
New pharmaceutical formulations of the oxime HI-6 as sustained-release and conventional tablets were studied in healthy… 
1984
1984
Isolation, in vitro activity, and acute toxicity in mice of the four stereoisomers of soman.
We report the isolation, on a 0.1- to 2-mg scale, of the four stereoisomers of the nerve agent pinacolyl… 
1983
1983
The effect of bis-pyridinium oximes on neuromuscular blockade induced by highly toxic organophosphates in rat.
Two bispyridinium oximes, BDB-27 and HGG-12, were tested in vivo for their ability to restore neuromuscular function in rats… 
1979
1979
Protective effect of dexetimide and HI-6 in poisoning with highly toxic organophosphorus compounds.
1978
1978
The Influence of 2-/o-cresyl/-4 H-1 ∶ 3 ∶ 2-benzodioxa-phosphorin-2-oxide (CBDP) on organophosphate poisoning and its therapy
The aim of the experiments was to obtain more information on the toxicity of organophosphates and protection against them… 
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