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asimadoline

Known as: N-methyl-N--(1-phenyl-2-(3-hydroxypyrrolidin-1-yl)ethyl)-2,2-diphenylacetamide hydrochloride 
 
National Institutes of Health

Papers overview

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Review
2015
Review
2015
Several chemically diverse pruritogens, including bombesin, compound 48/80, norbinaltorphimine, and 5'-GNTI, cause rodents to… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND In models of irritable bowel syndrome (IBS), asimadoline, a kappa-opioid agonist, improves pain and abnormal bowel… Expand
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Review
2008
Review
2008
  • Michael Camilleri
  • Neurogastroenterology and motility : the official…
  • 2008
  • Corpus ID: 25216551
Asimadoline is a potent kappa-opioid receptor agonist with a diaryl acetamide structure. It has high affinity for the kappa… Expand
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2007
2007
BACKGROUND & AIMS In experimental animal models of irritable bowel syndrome (IBS) and human studies, peripheral kappa opioid… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Visceral hypersensitivity plays a major role in irritable bowel syndrome pathophysiology. Opioid kappa receptors on… Expand
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2003
2003
To compare the effects of the kappa-opioid agonist asimadoline and placebo on visceral sensation and gastrointestinal (GI) motor… Expand
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2003
2003
AIM To evaluate the effect of single administrations of asimadoline, a kappa-opioid agonist, on satiation volume, postprandial… Expand
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Highly Cited
1999
Highly Cited
1999
Studies with knockout mice lacking mdr1a P-glycoprotein (P-gp) have previously shown that blood-brain barrier P-gp is important… Expand
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1999
1999
We have previously shown that kappa-opioids have antiarthritic properties. In this study, using two differently acting drugs (the… Expand
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1998
1998
1. Opioids, though widely used as analgesics, have not been seriously considered as therapy for rheumatoid arthritis. The present… Expand
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