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Background In models of irritable bowel syndrome (IBS), asimadoline, a kappa‐opioid agonist, improves pain and abnormal bowel… Expand Abstract Asimadoline is a potent κ‐opioid receptor agonist with a diaryl acetamide structure. It has high affinity for the… Expand Salvinorin (Sal) A is a naturally occurring, selective κ opioid receptor (KOPR) agonist with a short duration of action in vivo… Expand BACKGROUND & AIMS
In experimental animal models of irritable bowel syndrome (IBS) and human studies, peripheral kappa opioid… Expand Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand Background : Visceral hypersensitivity plays a major role in irritable bowel syndrome pathophysiology. Opioid κ receptors on… Expand To compare the effects of the kappa-opioid agonist asimadoline and placebo on visceral sensation and gastrointestinal (GI) motor… Expand Aim: To evaluate the effect of single administrations of asimadoline, a κ‐opioid agonist, on satiation volume, postprandial… Expand Studies with knockout mice lacking mdr1a P‐glycoprotein (P‐gp) have previously shown that blood‐brain barrier P‐gp is important… Expand We have previously shown that kappa‐opioids have antiarthritic properties. In this study, using two differently acting drugs (the… Expand