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asimadoline
Known as:
N-methyl-N--(1-phenyl-2-(3-hydroxypyrrolidin-1-yl)ethyl)-2,2-diphenylacetamide hydrochloride
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Acetamides
Pyrrolidines
Narrower (1)
EMD 61753
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Advances in Achieving Opioid Analgesia Without Side Effects
H. Machelska
,
M. Celik
Frontiers in Pharmacology
2018
Corpus ID: 53823064
Opioids are the most effective drugs for the treatment of severe pain, but they also cause addiction and overdose deaths, which…
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Highly Cited
2008
Highly Cited
2008
Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome
A. Mangel
,
J. D. Bornstein
,
+4 authors
D. Urso
Alimentary Pharmacology and Therapeutics
2008
Corpus ID: 23421430
Background In models of irritable bowel syndrome (IBS), asimadoline, a kappa‐opioid agonist, improves pain and abnormal bowel…
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Review
2008
Review
2008
Novel pharmacology: asimadoline, a κ‐opioid agonist, and visceral sensation
Michael Camilleri
Neurogastroenterology and Motility
2008
Corpus ID: 25216551
Abstract Asimadoline is a potent κ‐opioid receptor agonist with a diaryl acetamide structure. It has high affinity for the…
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Highly Cited
2008
Highly Cited
2008
Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors.
T. Vanderah
,
T. Largent-Milnes
,
+11 authors
P. Rivière
European Journal of Pharmacology
2008
Corpus ID: 38571458
Highly Cited
2008
Highly Cited
2008
2-Methoxymethyl-Salvinorin B Is a Potent κ Opioid Receptor Agonist with Longer Lasting Action in Vivo Than Salvinorin A
Yulin Wang
,
Yong Chen
,
+5 authors
L. Liu-Chen
Journal of Pharmacology and Experimental…
2008
Corpus ID: 2895061
Salvinorin (Sal) A is a naturally occurring, selective κ opioid receptor (KOPR) agonist with a short duration of action in vivo…
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Highly Cited
2006
Highly Cited
2006
Gateways to clinical trials.
M. Bayés
,
X. Rabasseda
,
J. Prous
Methods and Findings in Experimental and Clinical…
2006
Corpus ID: 30340641
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the…
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Highly Cited
2004
Highly Cited
2004
Effect of asimadoline, a κ opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome
M. Delvaux
,
A. Beck
,
Jutta Jacob
,
H. Bouzamondo
,
F. Weber
,
J. Frexinos
Alimentary Pharmacology and Therapeutics
2004
Corpus ID: 23570291
Background : Visceral hypersensitivity plays a major role in irritable bowel syndrome pathophysiology. Opioid κ receptors on…
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Highly Cited
2003
Highly Cited
2003
Effects of a kappa-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans.
S. Delgado-Aros
,
H. Chial
,
+7 authors
A. Zinsmeister
American Journal of Physiology - Gastrointestinal…
2003
Corpus ID: 9784591
To compare the effects of the kappa-opioid agonist asimadoline and placebo on visceral sensation and gastrointestinal (GI) motor…
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Highly Cited
1999
Highly Cited
1999
Role of blood‐brain barrier P‐glycoprotein in limiting brain accumulation and sedative side‐effects of asimadoline, a peripherally acting analgaesic drug
J. Jonker
,
E. Wagenaar
,
+4 authors
A. Schinkel
British Journal of Pharmacology
1999
Corpus ID: 38396025
Studies with knockout mice lacking mdr1a P‐glycoprotein (P‐gp) have previously shown that blood‐brain barrier P‐gp is important…
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1999
1999
Involvement of substance P in the anti‐inflammatory effects of the peripherally selective κ‐opioid asimadoline and the NK1 antagonist GR205171
W. Binder
,
C. Scott
,
J. Walker
European Journal of Neuroscience
1999
Corpus ID: 22649091
We have previously shown that kappa‐opioids have antiarthritic properties. In this study, using two differently acting drugs (the…
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