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asimadoline

Known as: N-methyl-N--(1-phenyl-2-(3-hydroxypyrrolidin-1-yl)ethyl)-2,2-diphenylacetamide hydrochloride 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AcetamidesPyrrolidines

Narrower (1)

EMD 61753

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
The kappa opioid receptor agonist SA14867 has antinociceptive and weak sedative effects in models of acute and chronic pain.
2010
2010
SA14867, a newly synthesized kappa-opioid receptor agonist with antinociceptive and antipruritic effects.
Review
2008
Review
2008
Asimadoline in the treatment of irritable bowel syndrome
Importance of the field: Irritable bowel syndrome (IBS) represents one of the most common gastrointestinal disorders, with the… 
2008
2008
Asimadoline, a kappa‐opioid agonist, and satiation in functional dyspepsia
Background  Asimadoline, a kappa‐opioid agonist, reduces visceral sensitivity in experimental animal models and may decrease… 
2006
2006
Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats
Aims/hypothesisWe investigated spinal and peripheral kappa opioid systems in diabetic rats.Materials and methodsDynorphin A, N… 
Review
2006
Review
2006
Peripheral Opioids for Functional GI Disease: A Reappraisal
Opioids have been used medicinally and recreationally for thousands of years. The clinical use of opioids for gastrointestinal… 
2001
2001
The kappa-opioid agonist, asimadoline, alters cytokine gene expression in adjuvant arthritis.
OBJECTIVE We have previously found that the kappa-opioid agonist, asimadoline, attenuates adjuvant arthritis in a dose-dependent… 
2000
2000
Involvement of K-opioid receptors in visceral nociception in mice
1999
1999
Lack of cross-tolerance between the antinociceptive effects of systemic morphine and asimadoline, a peripherally-selective κ-opioid agonist, in CCI-neuropathic rats
1998
1998
Effect of the peripherally selective kappa-opioid agonist, asimadoline, on adjuvant arthritis.
1. Opioids, though widely used as analgesics, have not been seriously considered as therapy for rheumatoid arthritis. The present… 
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