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asimadoline

Known as: N-methyl-N--(1-phenyl-2-(3-hydroxypyrrolidin-1-yl)ethyl)-2,2-diphenylacetamide hydrochloride 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Background  In models of irritable bowel syndrome (IBS), asimadoline, a kappa‐opioid agonist, improves pain and abnormal bowel… Expand
Review
2008
Review
2008
  • M. Camilleri
  • Neurogastroenterology and motility : the official…
  • 2008
  • Corpus ID: 25216551
Abstract  Asimadoline is a potent κ‐opioid receptor agonist with a diaryl acetamide structure. It has high affinity for the… Expand
2008
2008
Salvinorin (Sal) A is a naturally occurring, selective κ opioid receptor (KOPR) agonist with a short duration of action in vivo… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND & AIMS In experimental animal models of irritable bowel syndrome (IBS) and human studies, peripheral kappa opioid… Expand
Highly Cited
2006
Highly Cited
2006
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand
Highly Cited
2004
Highly Cited
2004
Background : Visceral hypersensitivity plays a major role in irritable bowel syndrome pathophysiology. Opioid κ receptors on… Expand
Highly Cited
2003
Highly Cited
2003
To compare the effects of the kappa-opioid agonist asimadoline and placebo on visceral sensation and gastrointestinal (GI) motor… Expand
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2003
2003
Aim:  To evaluate the effect of single administrations of asimadoline, a κ‐opioid agonist, on satiation volume, postprandial… Expand
Highly Cited
1999
Highly Cited
1999
Studies with knockout mice lacking mdr1a P‐glycoprotein (P‐gp) have previously shown that blood‐brain barrier P‐gp is important… Expand
1999
1999
We have previously shown that kappa‐opioids have antiarthritic properties. In this study, using two differently acting drugs (the… Expand