asimadoline

Known as: N-methyl-N--(1-phenyl-2-(3-hydroxypyrrolidin-1-yl)ethyl)-2,2-diphenylacetamide hydrochloride 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2018
02419972018

Papers overview

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2008
2008
BACKGROUND In models of irritable bowel syndrome (IBS), asimadoline, a kappa-opioid agonist, improves pain and abnormal bowel… (More)
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2008
2008
BACKGROUND Asimadoline, a kappa-opioid agonist, reduces visceral sensitivity in experimental animal models and may decrease… (More)
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2007
2007
BACKGROUND & AIMS In experimental animal models of irritable bowel syndrome (IBS) and human studies, peripheral kappa opioid… (More)
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2006
2006
We investigated spinal and peripheral kappa opioid systems in diabetic rats. Dynorphin A, N-methyl-d-aspartate (NMDA) and kappa… (More)
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2004
2004
BACKGROUND Visceral hypersensitivity plays a major role in irritable bowel syndrome pathophysiology. Opioid kappa receptors on… (More)
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2003
2003
To compare the effects of the kappa-opioid agonist asimadoline and placebo on visceral sensation and gastrointestinal (GI) motor… (More)
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2003
2003
AIM To evaluate the effect of single administrations of asimadoline, a kappa-opioid agonist, on satiation volume, postprandial… (More)
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1999
1999
Studies with knockout mice lacking mdr1a P-glycoprotein (P-gp) have previously shown that blood-brain barrier P-gp is important… (More)
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1999
1999
We have previously shown that kappa-opioids have antiarthritic properties. In this study, using two differently acting drugs (the… (More)
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1998
1998
1. Opioids, though widely used as analgesics, have not been seriously considered as therapy for rheumatoid arthritis. The present… (More)
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