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Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy
TLDR
The results clearly show that the neuropathy produces abnormal pain‐related disorders in the rat, which are reminiscent of those observed in some human neuropathies. Expand
Antinociceptive effects of acute and ‘chronic’ injections of tricyclic antidepressant drugs in a new model of mononeuropathy in rats
TLDR
This study showed that in this new model of mononeuropathy, acutely and chronically injected TCAs induce an antinociceptive effect and suggested that their analgesic action could be related to the monoaminergic spectrum of the drug in relation to the opiate systems. Expand
Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour
TLDR
Functional deficits in the GABAergic system may play an important role in the pathogenesis of this purely sensory rat model of trigeminal neuropathic pain. Expand
Experimental model of trigeminal pain in the rat by constriction of one infraorbital nerve: changes in neuronal activities in the somatosensory cortices corresponding to the infraorbital nerve
TLDR
It is questioned whether the disorganisation within the cortical map of the whisker pad, and the expanded RFs of vibrissa neurones could account for the abnormal pain-related reactions elicited from the massively deafferented trigeminal area. Expand
Neurones responding to noxious stimulation in VB complex and caudal adjacent regions in the thalamus of the rat
TLDR
A rostrocaudal organization of the cells, according to the location of their RF on the caudal or rostral part of the body, was clear not only for the Nn cells but also for N and NnN cells. Expand
Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat
TLDR
The modifications of the threshold for vocalization induced by pressure on the paws were monitored at different times following intraplantar injection of the polysaccharide carrageenin in the rat to observe the number of rats hyperalgesic in the injected paw progressively declined. Expand
Neuronal responsiveness in the ventrobasal thalamic complex of rats with an experimental peripheral mononeuropathy.
TLDR
Neurons, characterized by their responses to manual mechanical stimuli, were classified into two groups: group 1 neurons exclusively driven by light tactile stimuli applied to the receptive field (RF), strictly contralateral to the recording site; and group 2 neurons, driven by sustained pinch applied to a large RF, often bilateral. Expand
Combined systemic administration of the glycine/NMDA receptor antagonist, (+)-HA966 and morphine attenuates pain-related behaviour in a rat model of trigeminal neuropathic pain
TLDR
The present results indicate that combination therapy with NMDA/glycine receptor antagonists and morphine may be a useful approach for the clinical management of trigeminal neuropathic pain disorders. Expand
The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study
TLDR
The results suggest that damage to and/or loss of all caliber of peripheral axon contribute to the behavioral changes observed in this model of neuropathic pain. Expand
Estrous and sex variations in vocalization thresholds to hindpaw and tail pressure stimulation in the rat
TLDR
Sex and estrous differences in vocalization thresholds of rats to hindpaw and tail pressure stimulation tested daily throughout at least 3 weeks added to the growing list of important interacting factors that underly behavioral sensitivity to noxious somatic stimulation. Expand
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