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arzoxifene

A synthetic, aromatic derivative with anti-estrogenic properties. Similar to the agent raloxifene, arzoxifene binds to and interacts with estrogen… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

LY 353381
arzoxifene hydrochloride

Papers overview

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Review
2013
Review
2013
Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data
Summary Background Tamoxifen and raloxifene reduce the risk of breast cancer in women at elevated risk of disease, but the… Expand
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Review
2013
Review
2013
The Discovery and Development of Selective Estrogen Receptor Modulators (SERMs) for Clinical Practice
Selective estrogen receptor modulators (SERMs) are structurally different compounds that interact with intracellular estrogen… Expand
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Highly Cited
2011
Highly Cited
2011
Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women.
Arzoxifene is a selective estrogen receptor modulator (SERM) that has been shown to be more potent in preclinical testing than… Expand
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Highly Cited
2007
Highly Cited
2007
Phase III double-blind trial of arzoxifene compared with tamoxifen for locally advanced or metastatic breast cancer.
PURPOSE To compare the efficacy of arzoxifene with tamoxifen for the treatment of locally advanced or metastatic breast cancer… Expand
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Review
2006
Review
2006
Estrogen receptors as therapeutic targets in breast cancer.
The estrogen receptor alpha (ERalpha) has proven to be the single most important target in breast cancer over the last 30 years… Expand
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2004
2004
Breast Cancer Chemoprevention Phase I Evaluation of Biomarker Modulation by Arzoxifene, a Third Generation Selective Estrogen Receptor Modulator
Purpose: Arzoxifene, a new selective estrogen receptor modulator with strong breast antiestrogen activity and absence of uterine… Expand
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Highly Cited
2003
Highly Cited
2003
A phase II trial of arzoxifene, a selective estrogen response modulator, in patients with recurrent or advanced endometrial cancer.
OBJECTIVES The goal of this study was to determine response rate and evaluate toxicity of LY353381 (arzoxifene) in patients with… Expand
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Highly Cited
2002
Highly Cited
2002
Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques
The serotonin neural system contributes to cognition and affect, both of which exhibit pathologies with gender bias. We… Expand
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2002
2002
Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.
The selective estrogen receptor modulator arzoxifene and the rexinoid LG 100268 were active not only as single agents for… Expand
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Highly Cited
2001
Highly Cited
2001
Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer.
Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen… Expand
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