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Intravenous zoledronic acid in postmenopausal women with low bone mineral density.
Zoledronic acid infusions given at intervals of up to one year produce effects on bone turnover and bone density as great as those achieved with daily oral dosing with bisphosphonates with proven efficacy against fractures, suggesting that an annual infusion of zoledronic Acid might be an effective treatment for postmenopausal osteoporosis.
The management of patients with uterine sarcoma: a debated clinical challenge.
Serum tumor markers in the management of ovarian, endometrial and cervical cancer.
Symptoms of menopause — global prevalence, physiology and implications
- P. Monteleone, G. Mascagni, A. Giannini, A. Genazzani, T. Simoncini
- Medicine, PsychologyNature Reviews Endocrinology
- 2 February 2018
The goal of this Review is to describe in a timely manner new research findings on the global prevalence and physiology of menopausal symptoms and their impact on future health.
Non-genomic actions of sex steroid hormones.
The evidence collected in the past Years indicates that target cells and organs are regulated by a complex interplay of genomic and non-genomic signaling mechanisms of steroid hormones, and the integrated action of these machineries has important functional roles in a variety of pathophysiological processes.
Allopregnanolone concentrations and premenstrual syndrome.
It is hypothesized that patients with PMS may suffer from an inadequate production of ovarian neuroactive steroids, especially in the luteal phase, which would lead to an impaired anxiolytic GABA(A)-mediated response in stressful physiological and psychological conditions, and may in part explain various psychoneuroendocrine symptoms that arise during PMS.
Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm.
The present study is the first to demonstrate the presence of a diurnal rhythm of BDNF in humans, and the correlation found out between BDNF and cortisol circadian trend allows for speculate that these two factors may be physiologically co-regulated, in order to maintain the homeostasis of integrated cerebral activities.
Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms.
It is indicated that E(2) decreases VCAM-1 gene expression through the inhibition of NF-kappaB, AP-1, and GATA and suggest novel mechanisms for the antiatherogenic effect of estrogen on the vascular wall.
Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells.
Findings show significant differences in the signal transduction pathways recruited by P and MPA in endothelial cells, which may have relevant clinical implications.
Oregano: a source for peroxisome proliferator-activated receptor gamma antagonists.
- Monika Mueller, B. Lukas, J. Novak, T. Simoncini, A. Genazzani, A. Jungbauer
- BiologyJournal of agricultural and food chemistry
- 20 November 2008
Oregano extract and isolated compounds in the extract antagonize rosiglitazone-mediated DRIP205/TRAP220 recruitment to PPARgamma, pointing to oregano extracts as putative food supplements for weight reduction and preventing atherosclerosis by endothelial nitric oxide synthase activation.