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ABSTRACT The emergence and spread in Southeast Asia of Plasmodium falciparum resistance to artemisinin (ART) derivatives, the… Expand Building on insights gained from the discovery of the antimalarial ozonide arterolane (OZ277), we now describe the structure… Expand AbstractBackgroundChloroquine has been the treatment
of choice for acute vivax malaria for more than 60 years. Malaria caused by… Expand Antimalarial agents artemisinin and arterolane act via initial reduction of a peroxide bond in a process likely mediated by… Expand Arterolane (RBx11160, OZ277) maleate is a rapidly acting synthetic trioxolane anti‐malarial. This randomized, placebo controlled… Expand Artemisinin combination therapies (ACT) represent the current standard of care in the treatment of uncomplicated malaria. The… Expand Arterolane (RBx 11160) maleate is a novel, rapidly acting synthetic trioxolane antimalarial compound being developed by Ranbaxy… Expand The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency… Expand BACKGROUND
Drug-resistant Plasmodium falciparum malaria necessitates development of novel drugs for treatment.The present study… Expand ABSTRACT Peroxidic antimalarials such as the semisynthetic artemisinins are critically important in the treatment of drug… Expand