arachidonate 5-lipoxygenase activity

Known as: arachidonic 5-lipoxygenase activity, 5-delta-lipoxygenase activity, 5Delta-lipoxygenase activity 
Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. [EC:1.13.11.34]
National Institutes of Health

Papers overview

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2011
2011
Arachidonic acid metabolism has been implicated in colon carcinogenesis, but the role of hematopoietic 5-lipoxygenase (5LO) that… (More)
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2004
2004
Black cumin seed, Nigella sativa L., and its oils have traditionally been used for the treatment of asthma and other inflammatory… (More)
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2003
2003
Nonredox-type 5-lipoxygenase (5-LO) inhibitors such as ZM230487 or L-739.010 potently suppress leukotriene biosynthesis at low… (More)
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Highly Cited
1999
Highly Cited
1999
The natural polyphenolic compound resveratrol (trans-3,4', 5-trihydroxystilbene) is shown to prevent apoptosis (programmed cell… (More)
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Highly Cited
1993
Highly Cited
1993
Curcumine from Curcuma longa and the gum resin of Boswellia serrata, which were demonstrated to act as anti-inflammatories in in… (More)
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1993
1993
Transforming growth factor beta (TGF beta) increased the arachidonate 5-lipoxygenase (5-LO; EC 1.13.11.34) activity in HL-60… (More)
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1992
1992
The activity of lipoxygenase (LOX) in aged potato tuber discs increased by almost 2-fold following treatment of the discs with… (More)
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Highly Cited
1988
Highly Cited
1988
Challenge of human peripheral blood leukocytes with ionophore A23187 resulted in leukotriene (LT) synthesis, a decrease in total… (More)
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1988
1988
Severe cerebral vasospasm as confirmed by angiography was induced in dogs by injection of autologous blood into the cisterna… (More)
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1986
1986
The activity of leukotriene A4 (LTA4) synthase in crude human leukocyte homogenates was found to have a similar requirement for… (More)
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