arachidonate 5-lipoxygenase activity

Known as: arachidonic 5-lipoxygenase activity, 5-delta-lipoxygenase activity, 5Delta-lipoxygenase activity 
Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. [EC:1.13.11.34]
National Institutes of Health

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Arachidonate 5-Lipoxygenasearachidonate 12-lipoxygenase activity

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2011
2011
Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
Arachidonic acid metabolism has been implicated in colon carcinogenesis, but the role of hematopoietic 5-lipoxygenase (5LO) that… (More)
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2004
2004
Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone.
Black cumin seed, Nigella sativa L., and its oils have traditionally been used for the treatment of asthma and other inflammatory… (More)
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2003
2003
Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors.
Nonredox-type 5-lipoxygenase (5-LO) inhibitors such as ZM230487 or L-739.010 potently suppress leukotriene biosynthesis at low… (More)
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Highly Cited
1999
Highly Cited
1999
Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity.
The natural polyphenolic compound resveratrol (trans-3,4', 5-trihydroxystilbene) is shown to prevent apoptosis (programmed cell… (More)
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Highly Cited
1993
Highly Cited
1993
Mechanism of antiinflammatory actions of curcumine and boswellic acids.
Curcumine from Curcuma longa and the gum resin of Boswellia serrata, which were demonstrated to act as anti-inflammatories in in… (More)
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1993
1993
Transforming growth factor beta upregulates 5-lipoxygenase activity during myeloid cell maturation.
Transforming growth factor beta (TGF beta) increased the arachidonate 5-lipoxygenase (5-LO; EC 1.13.11.34) activity in HL-60… (More)
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1992
1992
Rapid stimulation of 5-lipoxygenase activity in potato by the fungal elicitor arachidonic Acid.
The activity of lipoxygenase (LOX) in aged potato tuber discs increased by almost 2-fold following treatment of the discs with… (More)
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Highly Cited
1988
Highly Cited
1988
Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.
Challenge of human peripheral blood leukocytes with ionophore A23187 resulted in leukotriene (LT) synthesis, a decrease in total… (More)
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1988
1988
Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after experimental subarachnoidal hemorrhage.
Severe cerebral vasospasm as confirmed by angiography was induced in dogs by injection of autologous blood into the cisterna… (More)
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1986
1986
Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.
The activity of leukotriene A4 (LTA4) synthase in crude human leukocyte homogenates was found to have a similar requirement for… (More)
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