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aprepitant

Known as: aprepitant [Chemical/Ingredient], (2R)-(1R)-3,5-bis(trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine, 3-(((2R,3S)-3-(P-Fluorophenyl)-2-(((alphar)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(2)-1,2,4-triazolin-5-one 
A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (3)

AntiemeticsMorpholinesNeurokinin-1 Receptor Antagonists
Drug AllergyNauseaVomitingaprepitant 40 MG Oral Capsule

Narrower (4)

EmendL 754030MK 0517MK 869

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
The Clinical Problem of Chemotherapy-Induced Nausea and Vomiting.
Beyond the current recommendations for management of chemotherapy-induced nausea and vomiting, recent research has shown… 
2016
2016
Development of Transdermal Delivery System of Dexamethasone, Palonosetron and Aprepitant for Combination Antiemetic Therapy
Purpose: The objective of this study was to assess the possible transdermal delivery for combination antiemetic therapy of… 
2014
2014
Dissolution Enhancement of Poorly Soluble Drug Aprepitant by Hot Melt Extrusion Method Using Hydrophilic Polymer: A Solid Dispersion Technique.
The objective of this study was to develop a solid dispersion method for enhancing the aqueous solubility of aprepitant (BCS… 
2014
2014
Tachykinin Peptide, Substance P, and Its Receptor Have a Significant Role in Tissue Reactions Induced by Cytotoxic Therapy
2014
2014
Papel del aprepitant en el manejo del prurito en un paciente con linfoma cutáneo de células T
Los linfomas cutáneos primarios constituyen el segun do grupo más frecuente de Linfoma No Hodgkin extranodal después de los… 
2012
2012
Aprepitant l- proline solvate - compositions and co-crystals
Aprepitant L- proline solvates compositions and aprepitant L- proline solvate co-crystals are disclosed as well as pharmaceutical… 
2010
2010
NETUPITANT, A POTENT AND HIGHLY SELECTIVE NK1 RECEPTOR ANTAGONIST IN THE GUINEA-PIG ISOLATED URINARY BLADDER: COMPARISON WITH APREPITANT
Hypothesis / aims of study Functional NK1 receptors have previously been demonstrated in guinea-pig urinary bladder smooth muscle… 
2010
2010
Aprepitant- A Novel Drug to Prevent Cancer Chemotherapy Induced Nausea and Vomiting
Introduction Nausea and vomiting are common and distressing side effects of the chemotherapy. However, the drugs used for… 
2008
2008
A prospective study on the incidence of delayed nausea and vomiting following administration of carboplatin-containing regimens for treatment of cancer without prophylactic aprepitant.
20626 Background: Delayed nausea and vomiting following administration of carboplatin containing chemotherapy regimen remains a… 
2006
2006
Validation of the electrical hyperalgesia model in human volunteers: effects of oral pregabalin and the NK1 antagonist aprepitant: A-884
Validation of the electrical hyperalgesia model in human volunteers: Effects of oral pregabalin and the NK1 antagonist aprepitant…