L 754030

The introduction of serotonin 5-HT3 receptor antagonists into clinical practice allowed for a dramatic improvement in the… Expand

1. Pandey CK, Priye S, Ambesh SP, Singh S, Singh U, Singh PK. Prophylactic gabapentin for prevention of postoperative nausea and… Expand

OBJECTIVE: To evaluate the safety and efficacy of aprepitant in the prevention of acute and delayed chemotherapy-induced nausea… Expand

PURPOSE The NK1-receptor antagonist MK-869 (L-754,030) has demonstrated antiemetic activity in humans receiving chemotherapy… Expand

Substance P is localised in brainstem regions associated with emesis. Based on studies in the ferret, it was postulated that a… Expand

The anti-emetic profile of the novel brain penetrant tachykinin NK1 receptor antagonist MK-0869 (L-754,030) 2-(R)-(1-(R)-(3,5-bis… Expand

I am grateful for the interest shown in my TiPS article1xNK1 (substance P) receptor antagonists – why are they not analgesic in… Expand

BACKGROUND The localization of substance P in brain-stem regions associated with vomiting, and the results of studies in ferrets… Expand

AIMS Following intravenous administration of its prodrug, L-758,298, we assessed the pharmacodynamics of L-754,030, a novel and… Expand

Chemotherapy-induced nausea and vomiting are important, distressing, and occasionally disabling problems that confound the… Expand