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L 754030

Known as: L 754,030, L-754,030, L-754030 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

aprepitant

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Potential of Substance P Antagonists as Antiemetics
The introduction of serotonin 5-HT3 receptor antagonists into clinical practice allowed for a dramatic improvement in the… Expand
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2006
2006
Intussuscepting giant liposarcoma of the oesophagus.
1. Pandey CK, Priye S, Ambesh SP, Singh S, Singh U, Singh PK. Prophylactic gabapentin for prevention of postoperative nausea and… Expand
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Review
2005
Review
2005
Aprepitant: A Novel Antiemetic for Chemotherapy-Induced Nausea and Vomiting
OBJECTIVE: To evaluate the safety and efficacy of aprepitant in the prevention of acute and delayed chemotherapy-induced nausea… Expand
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Highly Cited
2001
Highly Cited
2001
Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granisetron and dexamethasone or with dexamethasone alone.
PURPOSE The NK1-receptor antagonist MK-869 (L-754,030) has demonstrated antiemetic activity in humans receiving chemotherapy… Expand
Highly Cited
2001
Highly Cited
2001
Comparison of L-758,298, a prodrug for the selective neurokinin-1 antagonist, L-754,030, with ondansetron for the prevention of cisplatin-induced emesis.
Substance P is localised in brainstem regions associated with emesis. Based on studies in the ferret, it was postulated that a… Expand
Highly Cited
2000
Highly Cited
2000
The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets
The anti-emetic profile of the novel brain penetrant tachykinin NK1 receptor antagonist MK-0869 (L-754,030) 2-(R)-(1-(R)-(3,5-bis… Expand
2000
2000
Reply: will changing the testing paradigms show that NK1 receptor antagonists are analgesic in humans?
I am grateful for the interest shown in my TiPS article1xNK1 (substance P) receptor antagonists – why are they not analgesic in… Expand
Highly Cited
1999
Highly Cited
1999
Reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. L-754,030 Antiemetic Trials Group.
BACKGROUND The localization of substance P in brain-stem regions associated with vomiting, and the results of studies in ferrets… Expand
1999
1999
Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man.
AIMS Following intravenous administration of its prodrug, L-758,298, we assessed the pharmacodynamics of L-754,030, a novel and… Expand
Review
1999
Review
1999
Neurokinin Antagonism and Chemotherapy-Induced Emesis
Chemotherapy-induced nausea and vomiting are important, distressing, and occasionally disabling problems that confound the… Expand
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