FAQ

L 754030

Known as: L 754,030, L-754,030, L-754030 
 

Topic mentions per year

Topic mentions per year

1999-2005
02419992005

Related topics

Related topics

1 relation

Broader (1)

aprepitant

Related mentions per year

Related mentions per year

1999-2018
1990200020102020
L 754030
aprepitant

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Aprepitant: a novel antiemetic for chemotherapy-induced nausea and vomiting.
OBJECTIVE To evaluate the safety and efficacy of aprepitant in the prevention of acute and delayed chemotherapy-induced nausea… (More)
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Review
2002
Review
2002
MK 869. Aprepitant, L 754030, MK 0869.
  • Drugs in R&D
  • 2002
 
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2001
2001
Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granisetron and dexamethasone or with dexamethasone alone.
PURPOSE The NK1-receptor antagonist MK-869 (L-754,030) has demonstrated antiemetic activity in humans receiving chemotherapy… (More)
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2001
2001
Comparison of L-758,298, a prodrug for the selective neurokinin-1 antagonist, L-754,030, with ondansetron for the prevention of cisplatin-induced emesis.
Substance P is localised in brainstem regions associated with emesis. Based on studies in the ferret, it was postulated that a… (More)
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2000
2000
The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets.
The anti-emetic profile of the novel brain penetrant tachykinin NK1 receptor antagonist MK-0869 (L-754,030) 2-(R)-(1-(R)-(3,5-bis… (More)
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Review
2000
Review
2000
Potential of substance P antagonists as antiemetics.
The introduction of serotonin 5-HT3 receptor antagonists into clinical practice allowed for a dramatic improvement in the… (More)
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Highly Cited
1999
Highly Cited
1999
Reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. L-754,030 Antiemetic Trials Group.
BACKGROUND The localization of substance P in brain-stem regions associated with vomiting, and the results of studies in ferrets… (More)
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1999
1999
Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man.
AIMS Following intravenous administration of its prodrug, L-758,298, we assessed the pharmacodynamics of L-754,030, a novel and… (More)
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Review
1999
Review
1999
Neurokinin Antagonism and Chemotherapy-Induced Emesis
Chemotherapy-induced nausea and vomiting are important, distressing, and occasionally disabling problems that confound the… (More)
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1999
1999
Mk 869. L 754030, Mk 0869.
  • Drugs in R&D
  • 1999
 
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