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Neurokinin-1 Receptor Antagonists

Known as: Receptor Blockers, Neuroleukin-1, Receptor Antagonists, Neurokinin-1, Neurokinin 1 Receptor Antagonists 
Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.
National Institutes of Health

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AZD 2738AZD 8081CAM 4515CI 1021
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Use of neurokinin-1 receptor antagonists in patients receiving moderately or highly emetogenic chemotherapy.
Chemotherapy-induced nausea and vomiting (CINV) is a serious adverse effect of chemotherapy that limits patients' physical… 
2009
2009
Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]cyclopent-2-en… 
2009
2009
Synergy between microtubule destabilizing agents and neurokinin 1 receptor antagonists identified by an siRNA synthetic lethal screen
Coordinated microtubule polymerization and depolymerization is essential for numerous biological functions, including mitotic… 
2007
2007
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
A series of bifunctional peptides that act as agonists for delta and mu opioid receptors with delta selectivity and as antagonist… 
Review
2004
Review
2004
Potential therapeutic targets for neurokinin-1 receptor antagonists
The peptide substance P and its tachykinin receptor, neurokinin-1 (NK1), have been the focus of considerable research for their… 
2004
2004
Inhibiting substance p pathway for prevention of chemotherapy-induced emesis: preclinical data, clinical trials of neurokinin-1 receptor antagonists.
Neurokinin-1 (NK-1) receptor antagonists are a new class of antiemetic agents that have activity in controlling cisplatin-induced… 
Review
2004
Review
2004
Role of Neurokinin-1 Receptor Antagonists in Chemotherapy-Induced Emesis: Summary of Clinical Trials
Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life, and although… 
2001
2001
Neurokinin‐1 Receptor Antagonists Block Acute Cocaine‐Induced Horizontal Locomotion
Abstract: Systemic exposure to neurokinin‐1 receptor antagonists CP099994 or LY306740 prior to cocaine administration (10 mg/kg i… 
Highly Cited
1999
Highly Cited
1999
Tachykinin receptors are involved in the “local efferent” motor response to capsaicin in the guinea-pig small intestine and oesophagus
1999
1999
Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [Sar9,Met(O2)11]substance P
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