Neurokinin-1 Receptor Antagonists

The tachykinins, exemplified by substance P, are one of the most intensively studied neuropeptide families. They comprise a… Expand

Introduction: The substance P (SP)/neurokinin (NK)-1 receptor system is involved in many pathological processes. NK-1 receptor… Expand

The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need… Expand

Background:Neurokinins (e.g., substance P) contribute to pain transmission in the central nervous system, peripheral neurogenic… Expand

Previously, we have shown that primary afferent sensory neurons are necessary for disease activity in T cell-mediated immune… Expand

In this study the localizations of tachykinin neurokinin-1 (NK1) and neurokinin-3 (NK3) receptors in the guinea-pig brain are… Expand

The regioselective dibenzylphosphorylation of 2 followed by catalytic reduction in the presence of N-methyl-D-glucamine afforded… Expand

These experiments examined the role of substance P-selective neurokinin 1 receptors in the restraint-induced activation of the… Expand

Neuropathic pain is poorly managed by conventional analgesic therapy, such as non-steroidal anti-inflammatory drugs and opiates… Expand

Two non-peptide substance P antagonists exhibit opposite rank orders of potency for the human and rat neurokinin-1 receptors. CP… Expand