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Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
Hypoxia contributes to the progression of a variety of cancers by activating adaptive transcriptional programs that promote cell survival, motility and tumor angiogenesis. Although the importance ofExpand
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Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology.
MUTISM AND A variety of other neurobehavioral symptoms have been reported anecdotally after the removal of posterior fossa mass lesions. To determine the incidence and clinical spectrum of thisExpand
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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal amplifications of 15 knownExpand
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Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. AsExpand
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Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group.
To determine whether temozolomide is an active agent in the treatment of children with high-grade astrocytomas and whether survival is influenced by the expression of theExpand
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Spinal cord injury without radiographic abnormality in children--the SCIWORA syndrome.
Spinal cord injury in children frequently occurs without fracture or dislocation. The clinical profiles of 55 children with spinal cord injury without radiographic abnormalities (SCIWORA) areExpand
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Low-grade gliomas of the cerebral hemispheres in children: an analysis of 71 cases.
Low-grade gliomas constitute the largest group of cerebral hemispheric tumors in the pediatric population. Although complete tumor resection is generally the goal in the management of these lesions,Expand
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Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.
PURPOSE Surgery is curative therapy for pediatric low-grade gliomas (LGGs) in areas of the brain amenable to complete resection. However, LGGs located in areas where complete resection is notExpand
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The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood.
The prognosis for children with high-grade gliomas remains somewhat unpredictable. Although prolonged disease control is sometimes achieved after surgery, radiotherapy, and chemotherapy, mostExpand
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Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood.
Epidermal growth factor receptor (EGFR) is commonly overexpressed in adult high-grade gliomas. Forty to 50% of such tumors demonstrate amplification of the EGFR gene, often with rearrangement andExpand
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