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Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
Hypoxia contributes to the progression of a variety of cancers by activating adaptive transcriptional programs that promote cell survival, motility and tumor angiogenesis. Although the importance of… Expand
Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology.
MUTISM AND A variety of other neurobehavioral symptoms have been reported anecdotally after the removal of posterior fossa mass lesions. To determine the incidence and clinical spectrum of this… Expand
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal amplifications of 15 known… Expand
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As… Expand
Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group.
To determine whether temozolomide is an active agent in the treatment of children with high-grade astrocytomas and whether survival is influenced by the expression of the… Expand
Spinal cord injury without radiographic abnormality in children--the SCIWORA syndrome.
Spinal cord injury in children frequently occurs without fracture or dislocation. The clinical profiles of 55 children with spinal cord injury without radiographic abnormalities (SCIWORA) are… Expand
Low-grade gliomas of the cerebral hemispheres in children: an analysis of 71 cases.
- I. Pollack, D. Claassen, Q. Al-shboul, J. Janosky, M. Deutsch
- Journal of neurosurgery
- 1 April 1995
Low-grade gliomas constitute the largest group of cerebral hemispheric tumors in the pediatric population. Although complete tumor resection is generally the goal in the management of these lesions,… Expand
Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.
- J. Ater, T. Zhou, +10 authors I. Pollack
- Journal of clinical oncology : official journal…
- 20 July 2012
PURPOSE Surgery is curative therapy for pediatric low-grade gliomas (LGGs) in areas of the brain amenable to complete resection. However, LGGs located in areas where complete resection is not… Expand
The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood.
The prognosis for children with high-grade gliomas remains somewhat unpredictable. Although prolonged disease control is sometimes achieved after surgery, radiotherapy, and chemotherapy, most… Expand
Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood.
- M. Bredel, I. Pollack, R. Hamilton, C. James
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 July 1999
Epidermal growth factor receptor (EGFR) is commonly overexpressed in adult high-grade gliomas. Forty to 50% of such tumors demonstrate amplification of the EGFR gene, often with rearrangement and… Expand