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Responses of cerebral arteries and arterioles to acute hypotension and hypertension.
The responses of cerebral precapillary vessels to changes in arterial blood pressure were studied in anesthetized cats equipped with cranial windows for the direct observation of the pial
Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting.
Olanzapine, as compared with placebo, significantly improved nausea prevention, as well as the complete-response rate, among previously untreated patients who were receiving highly emetogenic chemotherapy.
Olanzapine versus aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a randomized phase III trial.
In this study, OLN combined with a single dose of DEX and a single doses of PAL was very effective at controlling acute and delayed CINV in patients receiving highly emetogenic chemotherapy.
Liposome‐encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first‐line therapy of metastatic breast carcinoma
The objective of this study was to compare the efficacy and toxicity of the liposome‐encapsulated doxorubicin, TLC D‐99 (Myocet, Elan Pharmaceuticals, Princeton, NJ), and conventional doxorubicin in
The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy
Olanzapine was significantly better than metoclopramide in the control of breakthrough emesis and nausea in patients receiving highly emetogenic chemotherapy.
Antimicrobial use in patients with advanced cancer receiving hospice care.
Symptom control may be the major indication for antimicrobial use for patients receiving hospice and palliative care, and antimicrobials controlled symptoms in the majority of the urinary tract infections, but were less effective in controlling symptoms in other sites of infection.
Reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. L-754,030 Antiemetic Trials Group.
The neurokinin-1-receptor antagonist L-754,030 prevents delayed emesis after treatment with cisplatin and combined with granisetron plus dexamethasone improves the prevention of acute emesis.
Pharmacological Management of Chemotherapy-Induced Nausea and Vomiting
Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life. The emetogenicity of the chemotherapeutic agents, repeated chemotherapy cycles and
Treatment of depressive symptoms in patients with early stage breast cancer undergoing adjuvant therapy
A high percentage of patients with newly diagnosed early stage breast cancer were found to have depressive symptoms prior to the initiation of adjuvant therapy and the use of fluoxetine for 6 months resulted in an improvement in quality of life, a higher completion of adjUvant treatment, and a reduction in depressive symptoms compared to patients who received placebo.
Symptomatic treatment of infections in patients with advanced cancer receiving hospice care.
Although the use of antimicrobials improved symptoms in the majority of patients with urinary tract infections, symptom control was less successful in infections of the respiratory tract, mouth/pharynx, skin/subcutaneous tissue, or blood.