FAQ

apomine

Known as: TETRAISOPROPYL 2-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)ETHYL-1,1-BIPHOSPHONATE, Tetraisopropyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethylidene-1,1-diphosphonate, tetraisopropyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-ethyl-1,1-bisphosphonate 
A 1,1-bisphosphonate ester with potential antineoplastic and hypocholesterolemic activities. SR-45023A binds to hydroxyapatite crystals in the bone… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2018
02419702018

Related topics

Related topics

4 relations

Broader (1)

Diphosphonates

Narrower (3)

SK&F 99085SR 45023ASR-9223i

Related mentions per year

Related mentions per year

1953-2018
1960198020002020
apomine
Diphosphonates
SR 45023A
SK&F 99085
SR-9223i

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth.
BACKGROUND Osteosarcoma is the most frequent malignant primary bone tumor that occurs mainly in the young, with an incidence peak… (More)
Is this relevant?
2010
2010
Study of the Bandgap of Synthesized Titanium Dioxide Nanoparticules Using the Sol-Gel Method and a Hydrothermal Treatment
In this work optical properties of titanium dioxide nanoparticles were studied. Titanium dioxide nanoparticles were synthesized… (More)
  • table 1
  • table 2
  • table 3
  • table 4
Is this relevant?
2009
2009
Preformulation, formulation, and in vivo efficacy of topically applied apomine.
Apomine is a novel compound that inhibits the mevalonate/isoprenoid pathway of cholesterol synthesis and may prove effective as a… (More)
Is this relevant?
2008
2008
Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice.
In mice, cocaine is detoxified to inactive products by butyrylcholinesterase (BChE) and carboxylesterase. In human beings… (More)
Is this relevant?
2007
2007
Tissue distribution and characterization of cholinesterase activity in six earthworm species.
To validate cholinesterase activity as a biomarker of pesticide exposure, we characterized the tissue distribution (whole body… (More)
Is this relevant?
2005
2005
Induction of apoptosis in breast cancer cells by apomine is mediated by caspase and p38 mitogen activated protein kinase activation.
The 1,1-bisphosphonate ester family member apomine (SR-45023A) is known to have anti-tumour activity in various cancer cell types… (More)
Is this relevant?
2004
2004
Population pharmacokinetics of APOMINE: a meta-analysis in cancer patients and healthy males.
AIMS 1) To characterize the population pharmacokinetics of apomine in healthy males and in male and female patients with solid… (More)
Is this relevant?
2000
2000
The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol.
Apomine (SR-45023A) is a new antineoplastic compound which is currently in clinical trials and representative of the family of… (More)
Is this relevant?
1994
1994
Butyrylcholinesterase regulates laminar retinogenesis of the chick embryo in vitro.
During chicken neurogenesis, the sequential expression of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) between… (More)
Is this relevant?
1984
1984
Role of aliesterase in organophosphate poisoning.
  • J. G. Clement
  • Fundamental and applied toxicology : official…
  • 1984
Various doses of CBDP (2-(2- methylphenoxy )-4H-1,3,2- benzodioxaphosphorin -2-oxide), a metabolite of tri-o-cresyl phosphate… (More)
Is this relevant?