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apomine
Known as:
TETRAISOPROPYL 2-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)ETHYL-1,1-BIPHOSPHONATE
, Tetraisopropyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethylidene-1,1-diphosphonate
, tetraisopropyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-ethyl-1,1-bisphosphonate
A 1,1-bisphosphonate ester with potential antineoplastic and hypocholesterolemic activities. SR-45023A binds to hydroxyapatite crystals in the bone…
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National Institutes of Health
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Related topics
Related topics
4 relations
Broader (1)
Diphosphonates
Narrower (3)
SK&F 99085
SR 45023A
SR-9223i
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Synthesis of beta-cyclodextrin-modified water-dispersible Ag-TiO2 core-shell nanoparticles and their photocatalytic activity.
Indrajit Shown
,
M. Ujihara
,
T. Imae
Journal of Nanoscience and Nanotechnology
2011
Corpus ID: 38707816
The beta-cyclodextrin-modified Ag-TiO2 core-shell nanoparticles were prepared by sodium borohydrate reduction of AgNO3 and the…
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2002
2002
Lizard cholinesterases as biomarkers of pesticide exposure: Enzymological characterization
J. Sanchez-Hernandez
,
Beatriz Sánchez
Environmental Toxicology and Chemistry
2002
Corpus ID: 45404510
Here we report the results of a study conducted to elucidate the enzymological characteristics of lizard cholinesterases (ChEs…
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2001
2001
Phase I pharmacokinetic trial and correlative in vitro phase II tumor kinetic study of Apomine (SR-45023A), a novel oral biphosphonate anticancer drug.
D. Alberts
,
A. Hallum
,
+7 authors
C. Bentzen
Clinical Cancer Research
2001
Corpus ID: 5997791
PURPOSE To study the human pharmacokinetics and in vitro cytotoxicity of Apomine, an p.o. administered, nonmyelosuppressive agent…
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1998
1998
Inhibition of the Enzymic Degradation of Suxamethonium and Mivacurium Increases the Onset Time of Submaximal Neuromuscular Block
T. M. Beaufort
,
V. Nigrović
,
J. Proost
,
M. Houwertjes
,
J. Wierda
Anesthesiology
1998
Corpus ID: 36753124
Background The factors that influence the onset time of submaximal (< 100%) neuromuscular block are not fully known. The authors…
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1995
1995
Some phosphonic acid analogs as inhibitors of pyrophosphate-dependent phosphofructokinase, a novel target in Toxoplasma gondii.
Z. Peng
,
J. M. Mansour
,
F. Araújo
,
J. Ju
,
C. McKenna
,
T. Mansour
Biochemical Pharmacology
1995
Corpus ID: 45186440
1994
1994
Butyrylcholinesterase regulates laminar retinogenesis of the chick embryo in vitro.
E. Willbold
,
P. Layer
European Journal of Cell Biology
1994
Corpus ID: 36832259
During chicken neurogenesis, the sequential expression of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) between…
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1992
1992
The effects of inhibition of plasma cholinesterase and hepatic microsomal enzyme activity on cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine blood levels in pigs.
J. Kambam
,
B. Mets
,
+4 authors
R. Kirsch
Journal of Laboratory and Clinical Medicine
1992
Corpus ID: 40703363
We measured the blood levels of cocaine and its three major metabolites, benzoylecgonine, ecgonine methyl ester, and norcocaine…
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1992
1992
Inhibition of pseudocholinesterase activity protects from cocaine-induced cardiorespiratory toxicity in rats.
J. Kambam
,
R. Naukam
,
M. Berman
Journal of Laboratory and Clinical Medicine
1992
Corpus ID: 20522198
We studied the effect of inhibition of pseudocholinesterase by a specific pseudocholinesterase inhibitor, tetraisopropyl…
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1989
1989
Vascular Cholinesterases and Choline Uptake in Isolated Rat Forebrain Microvessels: A Possible Link
M. Shimon
,
Y. Egozi
,
Y. Kloog
,
M. Sokolovsky
,
Sasson Cohen
Journal of Neurochemistry
1989
Corpus ID: 22218739
Abstract: The two parameters of the active [methyl‐3H]choline uptake into isolated rat forebrain microvessels, Km and Vmax, were…
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1985
1985
A human acetylcholinesterase gene identified by homology to the Ace region of Drosophila.
H. Soreq
,
D. Zevin-Sonkin
,
A. Avni
,
L. Hall
,
P. Spierer
Proceedings of the National Academy of Sciences…
1985
Corpus ID: 21636278
The Ace locus of the Drosophila genome controls biosynthesis of the neurotransmitter-hydrolyzing enzyme acetylcholinesterase…
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