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apomine

Known as: TETRAISOPROPYL 2-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)ETHYL-1,1-BIPHOSPHONATE, Tetraisopropyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethylidene-1,1-diphosphonate, tetraisopropyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-ethyl-1,1-bisphosphonate 
A 1,1-bisphosphonate ester with potential antineoplastic and hypocholesterolemic activities. SR-45023A binds to hydroxyapatite crystals in the bone… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Diphosphonates

Narrower (3)

SK&F 99085SR 45023ASR-9223i

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Synthesis of beta-cyclodextrin-modified water-dispersible Ag-TiO2 core-shell nanoparticles and their photocatalytic activity.
The beta-cyclodextrin-modified Ag-TiO2 core-shell nanoparticles were prepared by sodium borohydrate reduction of AgNO3 and the… 
2002
2002
Lizard cholinesterases as biomarkers of pesticide exposure: Enzymological characterization
Here we report the results of a study conducted to elucidate the enzymological characteristics of lizard cholinesterases (ChEs… 
2001
2001
Phase I pharmacokinetic trial and correlative in vitro phase II tumor kinetic study of Apomine (SR-45023A), a novel oral biphosphonate anticancer drug.
PURPOSE To study the human pharmacokinetics and in vitro cytotoxicity of Apomine, an p.o. administered, nonmyelosuppressive agent… 
1998
1998
Inhibition of the Enzymic Degradation of Suxamethonium and Mivacurium Increases the Onset Time of Submaximal Neuromuscular Block
Background The factors that influence the onset time of submaximal (< 100%) neuromuscular block are not fully known. The authors… 
1995
1995
Some phosphonic acid analogs as inhibitors of pyrophosphate-dependent phosphofructokinase, a novel target in Toxoplasma gondii.
1994
1994
Butyrylcholinesterase regulates laminar retinogenesis of the chick embryo in vitro.
During chicken neurogenesis, the sequential expression of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) between… 
1992
1992
The effects of inhibition of plasma cholinesterase and hepatic microsomal enzyme activity on cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine blood levels in pigs.
We measured the blood levels of cocaine and its three major metabolites, benzoylecgonine, ecgonine methyl ester, and norcocaine… 
1992
1992
Inhibition of pseudocholinesterase activity protects from cocaine-induced cardiorespiratory toxicity in rats.
We studied the effect of inhibition of pseudocholinesterase by a specific pseudocholinesterase inhibitor, tetraisopropyl… 
1989
1989
Vascular Cholinesterases and Choline Uptake in Isolated Rat Forebrain Microvessels: A Possible Link
Abstract: The two parameters of the active [methyl‐3H]choline uptake into isolated rat forebrain microvessels, Km and Vmax, were… 
1985
1985
A human acetylcholinesterase gene identified by homology to the Ace region of Drosophila.
The Ace locus of the Drosophila genome controls biosynthesis of the neurotransmitter-hydrolyzing enzyme acetylcholinesterase… 
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