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Acetylcholinesterase — new roles for an old actor
The discovery of the first neurotransmitter — acetylcholine — was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminatingExpand
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Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
Epidermal growth factor (EGF), through interaction with specific cell surface receptors, generates a pleiotropic response that, by a poorly defined mechanism, can induce proliferation of targetExpand
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Function of alternative splicing.
Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from the surprisingly low number of human genes. Unlike promoter activity, whichExpand
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Alteration of the microRNA network during the progression of Alzheimer's disease
An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing deregulation of 35Expand
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Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response
Pyridostigmine, a carbamate acetylcholinesterase (AChE) inhibitor, is routinely employed in the treatment of the autoimmune disease myasthenia gravis1. Pyridostigmine is also recommended by mostExpand
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Differentiation of Human Embryonic Stem Cells into Embryoid Bodies Comprising the Three Embryonic Germ Layers
BackgroundEmbryonic stem (ES) cells are lines of cells that are isolated from blastocysts. The murine ES cells were demonstrated to be true pluripotent cells as they differentiate into all embryonicExpand
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Structural roles of acetylcholinesterase variants in biology and pathology.
Apart from its catalytic function in hydrolyzing acetylcholine, acetylcholinesterase (AChE) affects cell proliferation, differentiation and responses to various insults, including stress. TheseExpand
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Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions
Mental stress modifies both cholinergic neurotransmission and alternative splicing in the brain, via incompletely understood mechanisms. Here, we report that stress changes brain microRNA (miR)Expand
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RACK1 has the nerve to act: Structure meets function in the nervous system
The receptor for activated protein kinase C 1 (RACK1) is an intracellular adaptor protein. Accumulating evidence attributes to this member of the tryptophan-aspartate (WD) repeat family the role ofExpand
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Virtues and woes of AChE alternative splicing in stress-related neuropathologies
The ACh hydrolyzing enzyme acetylcholinesterase (AChE) is a combinatorial series of proteins with variant N and C termini generated from alternate promoter usage and 3' alternative splicing. NeuronalExpand
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