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- Publications
- Influence
Acetylcholinesterase — new roles for an old actor
- H. Soreq, Shlomo Seidman
- Biology, Medicine
- Nature Reviews Neuroscience
- 1 April 2001
The discovery of the first neurotransmitter — acetylcholine — was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating… Expand
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
- T. Libermann, H. R. Nusbaum, +7 authors J. Schlessinger
- Biology, Medicine
- Nature
- 1985
Epidermal growth factor (EGF), through interaction with specific cell surface receptors, generates a pleiotropic response that, by a poorly defined mechanism, can induce proliferation of target… Expand
Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response
- A. Friedman, D. Kaufer, J. Shemer, I. Hendler, H. Soreq, I. Tur-Kaspa
- Medicine
- Nature Medicine
- 1 December 1996
Pyridostigmine, a carbamate acetylcholinesterase (AChE) inhibitor, is routinely employed in the treatment of the autoimmune disease myasthenia gravis1. Pyridostigmine is also recommended by most… Expand
Alteration of the microRNA network during the progression of Alzheimer's disease
- Pierre Lau, K. Bossers, +15 authors B. De Strooper
- Medicine, Biology
- EMBO molecular medicine
- 9 September 2013
An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing deregulation of 35… Expand
Function of alternative splicing.
- S. Stamm, S. Ben-Ari, +5 authors H. Soreq
- Medicine
- Gene
- 2005
Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from the surprisingly low number of human genes. Unlike promoter activity, which… Expand
Differentiation of Human Embryonic Stem Cells into Embryoid Bodies Comprising the Three Embryonic Germ Layers
- J. Itskovitz-Eldor, M. Schuldiner, +5 authors N. Benvenisty
- Biology, Medicine
- Molecular medicine
- 1 February 2000
BackgroundEmbryonic stem (ES) cells are lines of cells that are isolated from blastocysts. The murine ES cells were demonstrated to be true pluripotent cells as they differentiate into all embryonic… Expand
Structural roles of acetylcholinesterase variants in biology and pathology.
- D. Grisaru, M. Sternfeld, A. Eldor, D. Glick, H. Soreq
- Medicine, Biology
- European journal of biochemistry
- 15 September 1999
Apart from its catalytic function in hydrolyzing acetylcholine, acetylcholinesterase (AChE) affects cell proliferation, differentiation and responses to various insults, including stress. These… Expand
Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions
- A. Meerson, Luisa P Cacheaux, K. Goosens, R. Sapolsky, H. Soreq, D. Kaufer
- Biology, Medicine
- Journal of Molecular Neuroscience
- 1 August 2009
Mental stress modifies both cholinergic neurotransmission and alternative splicing in the brain, via incompletely understood mechanisms. Here, we report that stress changes brain microRNA (miR)… Expand
RACK1 has the nerve to act: Structure meets function in the nervous system
The receptor for activated protein kinase C 1 (RACK1) is an intracellular adaptor protein. Accumulating evidence attributes to this member of the tryptophan-aspartate (WD) repeat family the role of… Expand
NeurimmiRs: microRNAs in the neuroimmune interface.
Recent reports of microRNA (miR) modulators of both neuronal and immune processes (here termed NeurimmiRs) predict therapeutic potential for manipulating NeurimmiR levels in diseases affecting both… Expand