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apicularen A

Known as: apicularen 
 
National Institutes of Health

Papers overview

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2012
2012
The investigation of V-ATPases as potential therapeutic drug targets and hence of their specific inhibitors is a promising… Expand
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Highly Cited
2011
Highly Cited
2011
Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal lobar degeneration with ubiquitin and TAR… Expand
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Review
2011
Review
2011
V-ATPases in eukaryotes are heteromultimeric, H(+)-transporting proteins. They are localized in a multitude of different… Expand
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Review
2009
Review
2009
Acidity is one of the main features of the tumors. The V-ATPase is the primary responsible for the control of tumor… Expand
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2007
2007
PURPOSE Apicularen A has been shown to cause growth inhibition and apoptosis in several cancer cell lines. However, the… Expand
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2006
2006
Apicularen A and the known vacuolar-type (H(+))-ATPase (V-ATPase) inhibitor bafilomycin A(1) induced apoptosis of RAW 264.7 cells… Expand
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Highly Cited
2005
Highly Cited
2005
BackgroundV-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their… Expand
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2005
2005
We previously reported that apicularen A [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 dihydroxy… Expand
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2004
2004
Complete details of an asymmetric synthesis of apicularen (1) are described. The synthesis has been accomplished using a highly… Expand
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2003
2003
In RAW 264.7 cells, a mouse leukaemic monocyte cell line, apicularen A decreased cell growth and survival as assessed by 3-(4,5… Expand
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