apicularen A

Background: Apicularen is a specific V-ATPase inhibitor that binds to the VO complex of the holoenzyme. Results: Apicularen binds… Expand

Acidity is one of the main features of the tumors. The V-ATPase is the primary responsible for the control of tumor… Expand

[Structure: see text] A de novo approach to the formal total synthesis of the macrolide natural product (-)-apicularen A has been… Expand

BackgroundV-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their… Expand

Complete details of an asymmetric synthesis of apicularen (1) are described. The synthesis has been accomplished using a highly… Expand

Apicularen A (1) and related benzolactone acylenamines belong to a growing class of novel natural products possessing highly… Expand

A synthesis of apicularen precursor (-)-6 in 18 steps from D-glucal is reported. As (+)-6 has been converted into the potent… Expand

In RAW 264.7 cells, a mouse leukaemic monocyte cell line, apicularen A decreased cell growth and survival as assessed by 3‐(4,5… Expand

[reaction: see text] An approach to the macrocyclic core of apicularen A is described. Thus, cross-coupling of the aryl triflate… Expand

Abstract The potent cytostatic agent apicularen A belongs to a growing class of macrocyclic salicylates with unique biological… Expand