apicularen A

Known as: apicularen 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2013
012319982013

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2013
2013
Combination therapy is key to improving cancer treatment efficacy. Phorbol 12-myristate 13-acetate (PMA), a well-known PKC… (More)
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2012
2012
The investigation of V-ATPases as potential therapeutic drug targets and hence of their specific inhibitors is a promising… (More)
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2011
2011
Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal lobar degeneration with ubiquitin and TAR… (More)
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2007
2007
PURPOSE Apicularen A has been shown to cause growth inhibition and apoptosis in several cancer cell lines. However, the… (More)
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2006
2006
Apicularen A and the known vacuolar-type (H(+))-ATPase (V-ATPase) inhibitor bafilomycin A(1) induced apoptosis of RAW 264.7 cells… (More)
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2005
2005
V-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their localization in a… (More)
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2005
2005
We previously reported that apicularen A [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 dihydroxy… (More)
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2004
2004
Complete details of an asymmetric synthesis of apicularen (1) are described. The synthesis has been accomplished using a highly… (More)
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2003
2003
In RAW 264.7 cells, a mouse leukaemic monocyte cell line, apicularen A decreased cell growth and survival as assessed by 3-(4,5… (More)
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1998
1998
A novel macrolide, apicularen A, was produced by several species of the genus Chondromyces. Initially it was discovered by… (More)
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