apicularen A

The investigation of V-ATPases as potential therapeutic drug targets and hence of their specific inhibitors is a promising… Expand

Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal lobar degeneration with ubiquitin and TAR… Expand

V-ATPases in eukaryotes are heteromultimeric, H(+)-transporting proteins. They are localized in a multitude of different… Expand

Acidity is one of the main features of the tumors. The V-ATPase is the primary responsible for the control of tumor… Expand

PURPOSE Apicularen A has been shown to cause growth inhibition and apoptosis in several cancer cell lines. However, the… Expand

Apicularen A and the known vacuolar-type (H(+))-ATPase (V-ATPase) inhibitor bafilomycin A(1) induced apoptosis of RAW 264.7 cells… Expand

BackgroundV-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their… Expand

We previously reported that apicularen A [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 dihydroxy… Expand

Complete details of an asymmetric synthesis of apicularen (1) are described. The synthesis has been accomplished using a highly… Expand

In RAW 264.7 cells, a mouse leukaemic monocyte cell line, apicularen A decreased cell growth and survival as assessed by 3-(4,5… Expand