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Agrimonia eupatoria protects against chronic ethanol-induced liver injury in rats.
TLDR
It is suggested that AE ameliorates chronic ethanol-induced liver injury, and that protection is likely due to the suppression of oxidative stress and TLR-mediated inflammatory signaling. Expand
Suppression of inducible nitric oxide synthase expression in RAW 264. 7 macrophages by two beta-carboline alkaloids extracted from Melia azedarach.
TLDR
The results suggest that suppression of iNOS and cyclooxygenase-2 induction by lipopolysaccharide is responsible for the anti-inflammatory activity of these alkaloids through selective inhibition of the expression of genes, which play important roles in inflammatory signaling pathways. Expand
Apicularen A Induces Cell Death through Fas Ligand Up-Regulation and Microtubule Disruption by Tubulin Down-Regulation in HM7 Human Colon Cancer Cells
TLDR
Findings indicate that apicularen A is a promising new microtubule-targeting compound in vitro and anticancer activity in vivo. Expand
Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities
TLDR
Eriobotrya japonica showed strong cytotoxicity in ER‐negative breast cancer, cervix epitheloid (HeLa) and lung (A549) carcinoma cell lines, and in the antiproliferative assay, five human cancer cell lines representing different tissues were used. Expand
Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina
TLDR
The antioxidant activity was evaluated by the ORAC(Oxygen Radical Absorbance Capacity) assay, which measures scavenging activity against peroxy radicals induced by 2,2′-azobis (2-methoxypropion-amidine) dihydrochloride, and the value is expressed as relative trolox equivalent. Expand
Antitumor activity of some phenolic components in plants
The activity-guided fractionation of some medicinal plants led to yield five kinds of natural stilbene compounds namely 3,5-dihydroxy-4′-methoxystillbene(I), rhapontigenin(II), resveratrol (III),Expand
Two new lignans fromLindera obtusiloba blume
TLDR
Two new furanolignans (3, 5) were isolated from the stem of Lindera obtusiloba (Lauraceae) and showed cytotoxicity against a small panel of human tumor cell lines with ED50 values of 3.40∼19.27 μg/ml. Expand
Screening of estrogenic and antiestrogenic activities from medicinal plants.
The medicinal plant extracts commercially used in Asia were screened for their estrogenic and antiestrogenic activities in a recombinant yeast system featuring both a human estrogen receptor (ER)Expand
Inducible nitric oxide synthase inhibitors fromMelia azedarach var.Japonica
  • H. Kwon, B. Lee, +6 authors K. Lee
  • Chemistry, Medicine
  • Archives of pharmacal research
  • 1 August 1999
TLDR
In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two β-carboline alkaloids have been isolated from the cortex of Melia azedarach var.japonica and the structures were elucidated on the basis of spectroscopic data. Expand
Cytotoxic phenolic compounds from Chionanthus retusus
Cytotoxicity-guided fractionation and purification of MeOH extract from Chionanthus retusus Lindl. et Paxton resulted in the isolation of compounds. Fourteen phenolic compounds were isolated from theExpand
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