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antiprimod

Known as: ATIPRIMOD, N,N-Diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine 
An orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and… 
National Institutes of Health

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3 relations
Atiprimod Dimaleateazaspirane

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SK&F 106615

Papers overview

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2019
2019
Atiprimod induce apoptosis in pituitary adenoma: Endoplasmic reticulum stress and autophagy pathways
Pituitary adenoma is the most common tumor with a high recurrence rate due to a hormone‐dependent JAK/signal transducer and… 
2012
2012
Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo.
2008
2008
A Severe Combined Immunodeficient–hu In vivo Mouse Model of Human Primary Mantle Cell Lymphoma
Purpose: To establish a severe combined immunodeficient (SCID)-hu in vivo mouse model of human primary mantle cell lymphoma (MCL… 
2008
2008
Phase II proof-of-concept study of atiprimod in patients with advanced low- to intermediate-grade neuroendocrine carcinoma
4611 Background: Effective systemic therapies for carcinoid tumors are lacking. No therapy to date has been shown to prolong… 
2007
2007
Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma
Atiprimod (Atip) is a novel oral agent with anti-inflammatory properties. Although its in vitro activity and effects on signaling… 
2007
2007
Atiprimod: a multi-functional drug candidate for myeloid and other malignancies.
2006
2006
Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways.
Atiprimod is a novel cationic amphiphilic compound and has been shown to exert antimyeloma effects both in vitro and in mouse… 
2006
2006
Phase I study of the safety and efficacy of atiprimod, a novel azaspirine, for patients with advanced cancer.
13050 Background: Atiprimod (N-N-diethl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) is an oral cationic azaspirane that… 
2005
2005
A Phase I, Multi-Center, Dose Escalation Study of Atiprimod in Patients with Refractory or Relapsed Multiple Myeloma (MM).
Atiprimod (N-N-diethl-8, 8-dipropyl-2-azaspiro [4,5] decane-2-propanamine) is an orally bioavailable cationic amphilic compound… 
2004
2004
Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis.
Atiprimod, a novel compound belonging to the azaspirane class of cationic amphiphilic drugs, exhibits both anti-proliferative and… 
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