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anthrapyrazole

Known as: oxanthrazole 
An antineoplastic antibiotic that intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

Anthracycline AntibioticsAnthracyclinesAnthrapyrazole Antineoplastic Antibiotic
CI 942NCIt Antineoplastic Agent TerminologyPiroxantrone HClpiroxantrone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Hypoxia activated prodrugs of a 9-aza-anthrapyrazole derivative that has promising anticancer activity.
Mono- and bis-N-oxides of a 9-aza-anthrapyrazole derivative having two 2-(dimethylamino)ethyl appendages were prepared by using a… 
2005
2005
BBR 3438, a novel 9-aza-anthrapyrazole, in patients with advanced gastric cancer: A phase II study group trial of the central European Society of Anticancer-Drug Research (CESAR)
BBR 3438, a member of the 9-aza-anthrapyrazole family designed to decrease anthracycline dependent cardiotoxicity and to improve… 
1996
1996
A comparison of methods for limited-sampling strategy design using data from a phase I trial of the anthrapyrazole DuP-941
Abstract The pharmacokinetics of a drug in individual patients can be estimated using plasma samples collected at a limited… 
1995
1995
Interstitial laser photochemotherapy with new anthrapyrazole drugs for the treatment of xenograft tumors.
Photodynamic therapy (PDT) with lasers and new dyes has gained popularity in recent years as a minimally invasive technique with… 
1994
1994
Aliphatic amine N-oxides of DNA binding agents as bioreductive drugs.
The DNA binding and cytotoxicity of four intercalating agents, namely bis-alkylamino (-N(CH2)2N(CH3)2) substituted anthraquinone… 
1990
1990
Phase I and clinical pharmacological evaluation of pirozantrone hydrochloride (oxantrazole).
Pirozantrone hydrochloride, an anthrapyrazole analogue, was selected for clinical evaluation based on broad antitumor activity… 
1989
1989
PHOTOSENSITIZATION OF ANTICANCER AGENTS‐8. ONE‐ELECTRON REDUCTION OF MITOXANTRONE: AN EPR AND SPECTROPHOTOMETRIC STUDY
An efficient method of one‐electron reduction of the anticancer agent mitoxantrone is described. The method depends on… 
1989
1989
Development of a radioimmunoassay for the anthrapyrazole chemotherapy agent CI-937 and the pharmacokinetics of CI-937 in rats.
The anthracyclines daunorubicin and doxorubicin are cancer chemotherapy agents that complex DNA and are widely utilized… 
1987
1987
High-performance liquid chromatographic assay for the experimental anticancer agent oxantrazole.
1987
1987
A theoretical study of the intercalative binding of the anti-tumour drug anthrapyrazole to double-stranded oligonucleotides.
Theoretical computations have been performed on the intercalative binding of anthrapyrazole to the double-stranded… 
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