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anthrapyrazole

Known as: oxanthrazole 
An antineoplastic antibiotic that intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family, and its function is critical for signal… Expand
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Highly Cited
1999
Highly Cited
1999
Selection for in vitro drug resistance can result in a complex phenotype with more than one mechanism of resistance emerging… Expand
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1996
1996
Abstract The pharmacokinetics of a drug in individual patients can be estimated using plasma samples collected at a limited… Expand
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1994
1994
The DNA binding and cytotoxicity of four intercalating agents, namely bis-alkylamino (-N(CH2)2N(CH3)2) substituted anthraquinone… Expand
1991
1991
We performed a phase I trial of CI-937 (DUP937), an anthrapyrazole, with the following objectives: (a) to determine the maximally… Expand
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1989
1989
This assay has facilitated the accurate determination of the pharmacokinetics of the drug in patients treated at the phase I… Expand
1989
1989
An efficient method of one‐electron reduction of the anticancer agent mitoxantrone is described. The method depends on… Expand
1988
1988
Single-strand breaks can be introduced into PM2 closed-circular DNA upon illumination with blue light, in the presence of the… Expand
1986
1986
A novel anthrapyrazole anticancer agent has been examined for photosensitizing properties. Illumination of the anthrapyrazole and… Expand
1986
1986
EPR and spin-trapping techniques were employed to study the oxidation of the dihydronicotinamide adenine dinucleotide (NADH… Expand