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anthrapyrazole

Known as: oxanthrazole 
An antineoplastic antibiotic that intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA… Expand
National Institutes of Health

Papers overview

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2005
2005
c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family, and its function is critical for signal… Expand
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Highly Cited
1999
Highly Cited
1999
Selection for in vitro drug resistance can result in a complex phenotype with more than one mechanism of resistance emerging… Expand
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1996
1996
Abstract The pharmacokinetics of a drug in individual patients can be estimated using plasma samples collected at a limited… Expand
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1995
1995
Photodynamic therapy (PDT) with lasers and new dyes has gained popularity in recent years as a minimally invasive technique with… Expand
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1994
1994
The DNA binding and cytotoxicity of four intercalating agents, namely bis-alkylamino (-N(CH2)2N(CH3)2) substituted anthraquinone… Expand
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1991
1991
We performed a phase I trial of CI-937 (DUP937), an anthrapyrazole, with the following objectives: (a) to determine the maximally… Expand
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1989
1989
This assay has facilitated the accurate determination of the pharmacokinetics of the drug in patients treated at the phase I… Expand
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1989
1989
SummaryOxantrazole (now designated as piroxantrone) is an anthrapyrazole analog under evaluation as a potentially useful… Expand
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1989
1989
SummaryCI-941 is a new synthetic DNA-binding agent selected for phase I clinical evaluation. The drug has broad-spectrum… Expand
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1988
1988
Single-strand breaks can be introduced into PM2 closed-circular DNA upon illumination with blue light, in the presence of the… Expand
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