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androgen biosynthetic process
Known as:
androgen synthesis
, androgen formation
, androgen anabolism
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The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual…
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National Institutes of Health
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Highly Cited
2017
Highly Cited
2017
Abiraterone plus Prednisone in Metastatic, Castration‐Sensitive Prostate Cancer
K. Fizazi
,
N. Tran
,
+12 authors
K. Chi
New England Journal of Medicine
2017
Corpus ID: 22458670
Background Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic…
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Highly Cited
2013
Highly Cited
2013
Abiraterone in metastatic prostate cancer without previous chemotherapy.
C. Ryan
,
M. Smith
,
+30 authors
D. Rathkopf
New England Journal of Medicine
2013
Corpus ID: 261942836
BACKGROUND Abiraterone acetate, an androgen biosynthesis inhibitor, improves overall survival in patients with metastatic…
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Highly Cited
2011
Highly Cited
2011
Abiraterone and increased survival in metastatic prostate cancer.
J. D. de Bono
,
C. Logothetis
,
+29 authors
H. Scher
New England Journal of Medicine
2011
Corpus ID: 2099591
BACKGROUND Biosynthesis of extragonadal androgen may contribute to the progression of castration-resistant prostate cancer. We…
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Highly Cited
2011
Highly Cited
2011
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.
Changmeng Cai
,
Sen Chen
,
+9 authors
S. Balk
Cancer Research
2011
Corpus ID: 2680011
Relapse of castration-resistant prostate cancer (CRPC) that occurs after androgen deprivation therapy of primary prostate cancer…
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Highly Cited
2005
Highly Cited
2005
Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition.
R. Kaaks
,
S. Rinaldi
,
+38 authors
E. Riboli
Endocrine-Related Cancer
2005
Corpus ID: 24088089
Considerable experimental and epidemiological evidence suggests that elevated endogenous sex steroids - notably androgens and…
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Review
1997
Review
1997
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.
A. Dunaif
Endocrine reviews
1997
Corpus ID: 654960
It is now clear that PCOS is often associated with profound insulin resistance as well as with defects in insulin secretion…
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Highly Cited
1994
Highly Cited
1994
Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17.
Adam Carey
,
D. Waterworth
,
+5 authors
R. Williamson
Human Molecular Genetics
1994
Corpus ID: 22503350
Fourteen Caucasian families with 81 affected individuals have been assessed in which polycystic ovaries/male pattern baldness…
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Review
1994
Review
1994
Follicular oestrogen synthesis: the ‘two-cell, two-gonadotrophin’ model revisited
S. Hillier
,
P. Whitelaw
,
C. Smyth
Molecular and Cellular Endocrinology
1994
Corpus ID: 45313255
Highly Cited
1990
Highly Cited
1990
Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.
A. Gazdar
,
H. Oie
,
+9 authors
R. Rocca
Cancer Research
1990
Corpus ID: 12746279
We established a continuous cell line, NCI-H295, from an invasive primary adrenocortical carcinoma. The cell line was established…
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Highly Cited
1987
Highly Cited
1987
Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis.
A. Hsueh
,
K. Dahl
,
+4 authors
W. Vale
Proceedings of the National Academy of Sciences…
1987
Corpus ID: 22590615
Inhibin, a gonadal hormone capable of preferential suppression of pituitary follicle-stimulating hormone (FSH) secretion, has…
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