The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
- H. Oh, Steven B. Bradfute, Michael D. Schneider
- Biology, MedicineProceedings of the National Academy of Sciences…
- 6 October 2003
The existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1.5 is reported, and differentiation was shown to occur roughly equally, with and without fusion to host cells.
Sox9 is required for cartilage formation
- W. Bi, J. Deng, Zhaoping Zhang, R. Behringer, B. Crombrugghe
- Biology, MedicineNature Genetics
- 29 April 1999
The results identify Sox9 as the first transcription factor that is essential for chondrocyte differentiation and cartilage formation and Sox9 is identified as a regulator of the chondROcyte lineage.
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
Mgp, a mineral-binding ECM protein3 synthesized by vascular smooth-muscle cells and chondrocytes, is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo.
Requirement for Wnt3 in vertebrate axis formation
- P. Liu, M. Wakamiya, M. J. Shea, U. Albrecht, R. Behringer, A. Bradley
- BiologyNature Genetics
- 1 August 1999
It is shown that Wnt3 is expressed before gastrulation in the proximal epiblast of the egg cylinder, then is restricted to the posterior proximalEpiblast and its associated visceral endoderm and subsequently to the primitive streak and mesoderm, and the subsequent establishment of anterior-posterior neural pattern in the ectoderm is dependent on derivatives of the primitive streaks.
Fgf9 and Wnt4 Act as Antagonistic Signals to Regulate Mammalian Sex Determination
It is shown through gain- and loss-of-function experiments that fibroblast growth factor 9 (FGF9) and WNT4 act as opposing signals to regulate sex determination, and the fate of the gonad is controlled by antagonism between Fgf9 and Wnt4.
Col2a1‐directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice
Type II collagen is one of the principal markers of chondrocyte differentiation and is encoded by the proa1(II) collagen gene (Col2a1) (Cheah et al., 1985), and to analyze the expression pattern of Cre recombinase in transgenic mice, the ROSA26 Cre reporter mouse strain was utilized.
Requirement for LIml in head-organizer function
A targeted deletion of the Liml gene was generated in embryonic stem cells and it was found that embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally.
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
It is shown that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone, which suggests interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status.
Requirement of Bmpr1a for Müllerian duct regression during male sexual development
Targeted disruption of the widely expressed type I bone morphogenetic protein receptor Bmpr1a in the mesenchymal cells of the Müllerian ducts leads to retention of oviducts and uteri in males, indicating that a component of the BMP signaling pathway has been co-opted during evolution for male sexual development in amniotes.