anaphase-promoting complex location

Known as: anaphase promoting complex, APC, anaphase promoting complex location 
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit… (More)
National Institutes of Health

Papers overview

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Review
2015
Review
2015
The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent… (More)
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Highly Cited
2014
Highly Cited
2014
The ubiquitination of cell cycle regulatory proteins by the anaphase-promoting complex/cyclosome (APC/C) controls sister… (More)
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Highly Cited
2009
Highly Cited
2009
Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the protein ubiquitylation… (More)
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Highly Cited
2009
Highly Cited
2009
Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these… (More)
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Review
2008
Review
2008
The maintenance and preservation of distinct phases during the cell cycle is a highly complex and coordinated process. It is… (More)
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Review
2006
Review
2006
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic… (More)
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Review
2006
Review
2006
A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the activities of which are controlled by… (More)
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Highly Cited
2003
Highly Cited
2003
The anaphase-promoting complex (APC) or cyclosome is a ubiquitin ligase that initiates anaphase and mitotic exit. APC activation… (More)
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Highly Cited
1998
Highly Cited
1998
Proteolysis mediated by the anaphase promoting complex (APC) has a crucial role in regulating the passage of cells through… (More)
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Highly Cited
1998
Highly Cited
1998
Cohesion between sister chromatids during G2 and M phases depends on the "cohesin" protein Scc1p (Mcd1p). Loss of cohesion at the… (More)
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