anaphase-promoting complex location

Known as: anaphase promoting complex, APC, anaphase promoting complex location 
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit… (More)
National Institutes of Health

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anaphase-promoting complex

Papers overview

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Review
2015
Review
2015
Spatiotemporal regulation of the anaphase-promoting complex in mitosis
The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent… (More)
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Highly Cited
2014
Highly Cited
2014
Molecular architecture and mechanism of the anaphase-promoting complex
The ubiquitination of cell cycle regulatory proteins by the anaphase-promoting complex/cyclosome (APC/C) controls sister… (More)
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Highly Cited
2009
Highly Cited
2009
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.
Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the protein ubiquitylation… (More)
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Highly Cited
2009
Highly Cited
2009
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these… (More)
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Review
2008
Review
2008
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
The maintenance and preservation of distinct phases during the cell cycle is a highly complex and coordinated process. It is… (More)
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Review
2006
Review
2006
The anaphase promoting complex/cyclosome: a machine designed to destroy
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic… (More)
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Review
2006
Review
2006
Ubiquitin ligases: cell-cycle control and cancer
A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the activities of which are controlled by… (More)
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Highly Cited
2003
Highly Cited
2003
Mitotic regulation of the human anaphase-promoting complex by phosphorylation.
The anaphase-promoting complex (APC) or cyclosome is a ubiquitin ligase that initiates anaphase and mitotic exit. APC activation… (More)
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Highly Cited
1998
Highly Cited
1998
The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.
Proteolysis mediated by the anaphase promoting complex (APC) has a crucial role in regulating the passage of cells through… (More)
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Highly Cited
1998
Highly Cited
1998
An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast
Cohesion between sister chromatids during G2 and M phases depends on the "cohesin" protein Scc1p (Mcd1p). Loss of cohesion at the… (More)
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