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anaphase-promoting complex location

Known as: anaphase promoting complex, APC, anaphase promoting complex location 
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit… Expand
National Institutes of Health

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anaphase-promoting complex

Papers overview

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Review
2019
Review
2019
Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.
The anaphase promoting complex/cyclosome (APC/C) E3 ligase controls mitosis and nonmitotic pathways through interactions with… Expand
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Highly Cited
2009
Highly Cited
2009
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these… Expand
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Review
2008
Review
2008
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
The maintenance and preservation of distinct phases during the cell cycle is a highly complex and coordinated process. It is… Expand
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Review
2006
Review
2006
The anaphase promoting complex/cyclosome: a machine designed to destroy
  • J. Peters
  • Nature Reviews Molecular Cell Biology
  • 2006
    • Corpus ID: 31962403
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic… Expand
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Review
2006
Review
2006
Ubiquitin ligases: cell-cycle control and cancer
A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the activities of which are controlled by… Expand
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Review
2005
Review
2005
On the road to cancer: aneuploidy and the mitotic checkpoint
Abnormal chromosome content — also known as aneuploidy — is the most common characteristic of human solid tumours. It has… Expand
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Highly Cited
2001
Highly Cited
2001
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase… Expand
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Highly Cited
1998
Highly Cited
1998
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR‐mediated protein–protein interactions
The tetratricopeptide repeat (TPR) is a degenerate 34 amino acid sequence identified in a wide variety of proteins, present in… Expand
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Highly Cited
1998
Highly Cited
1998
Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex.
Proteolysis of mitotic cyclins depends on a multisubunit ubiquitin-protein ligase, the anaphase promoting complex (APC… Expand
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Highly Cited
1995
Highly Cited
1995
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis. Previous work with cell-free… Expand
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