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anaphase-promoting complex

Known as: Anaphase Promoting Complex, Anaphase-Promoting Complex-Cyclosome, Anaphase-Promoting Complex-Cyclosome [Chemical/Ingredient] 
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific… Expand
National Institutes of Health

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In BloodProcess of secretionanaphase-promoting complex locationantagonists & inhibitors
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Papers overview

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2017
2017
Erratum: The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
[This corrects the article DOI: 10.1038/ncomms15751.]. 
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2012
2012
Proteasome-Dependent Disruption of the E3 Ubiquitin Ligase Anaphase-Promoting Complex by HCMV Protein pUL21a
The anaphase-promoting complex (APC) is an E3 ubiquitin ligase which controls ubiquitination and degradation of multiple cell… Expand
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2012
2012
Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.
Cytoskeleton-associated proteins play key roles not only in regulating cell morphology and migration but also in proliferation… Expand
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2012
2012
Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells.
Cancers that develop in BRCA1 mutation carriers are usually near tetraploid/polyploid. This led us to hypothesize that BRCA1… Expand
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2010
2010
Substrate degradation by the anaphase promoting complex occurs during mitotic slippage.
Microtubule targeting drugs are successful in chemotherapy because they indefinitely activate the spindle assembly checkpoint… Expand
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2010
2010
Requirements and Reasons for Effective Inhibition of the Anaphase Promoting Complex Activator Cdh1
Anaphase promoting complex (APC)-Cdh1 targets multiple mitotic proteins for degradation upon exit from mitosis into G1… Expand
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Review
2010
Review
2010
Tension Management in the Kinetochore
The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic… Expand
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Review
2010
Review
2010
ReviewTension Management in the Kinetochore
The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic… Expand
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2007
2007
Regulation of Gene Expression in Bovine Blastocysts in Response to Oxygen and the Iron Chelator Desferrioxamine1
Abstract Low (2%) oxygen conditions during postcompaction culture of bovine blastocysts improve embryo quality and are associated… Expand
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Highly Cited
2004
Highly Cited
2004
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.
Progression through mitosis requires activation of cyclin B/Cdk1 and its downstream targets, including Polo-like kinase and the… Expand
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