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anaphase-promoting complex

Known as: Anaphase Promoting Complex, Anaphase-Promoting Complex-Cyclosome, Anaphase-Promoting Complex-Cyclosome [Chemical/Ingredient] 
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
01220022018

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In BloodProcess of secretionanaphase-promoting complex locationantagonists & inhibitors
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MND2 protein, S cerevisiae

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
anaphase-promoting complex
physiological aspects
In Blood
chemical synthesis
anaphase-promoting complex location
standards characteristics

Papers overview

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2015
2015
Multiple Requirements of PLK1 during Mouse Oocyte Maturation
Polo-like kinase 1 (PLK1) orchestrates multiple events of cell division. Although PLK1 function has been intensively studied in… (More)
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2013
2013
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
Pituitary tumour transforming gene (pttg1) encodes Securin, a protein involved in the inhibition of sister chromatid separation… (More)
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2012
2012
Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.
Cytoskeleton-associated proteins play key roles not only in regulating cell morphology and migration but also in proliferation… (More)
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2012
2012
Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells.
Cancers that develop in BRCA1 mutation carriers are usually near tetraploid/polyploid. This led us to hypothesize that BRCA1… (More)
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2010
2010
Requirements and Reasons for Effective Inhibition of the Anaphase Promoting Complex Activator Cdh1
Anaphase promoting complex (APC)-Cdh1 targets multiple mitotic proteins for degradation upon exit from mitosis into G1… (More)
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2007
2007
Characterization of the Apc10/Doc1 subunit of the anaphase promoting complex in Drosophila melanogaster.
The anaphase promoting complex or cyclosome (APC/C) is a large protein complex with an ubiquitin ligase activity which… (More)
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2006
2006
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
The human T-lymphotropic virus type 1 (HTLV-1) Tax binds the anaphase promoting complex (APC) and activates it ahead of schedule… (More)
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Highly Cited
2004
Highly Cited
2004
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.
Progression through mitosis requires activation of cyclin B/Cdk1 and its downstream targets, including Polo-like kinase and the… (More)
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Highly Cited
2004
Highly Cited
2004
Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis.
Polo-like kinase-1 (Plk1) performs multiple essential functions during the cell cycle. Here we show that human Plk1-deficient… (More)
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2002
2002
The anaphase promoting complex/cyclosome is required during development for modified cell cycles.
Animals and plants use modified cell cycles to achieve particular developmental strategies. In one common example, most animals… (More)
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