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anaphase-promoting complex

Known as: Anaphase Promoting Complex, Anaphase-Promoting Complex-Cyclosome, Anaphase-Promoting Complex-Cyclosome [Chemical/Ingredient] 
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific… Expand
National Institutes of Health

Related topics

Related topics

8 relations
In BloodProcess of secretionanaphase-promoting complex locationantagonists & inhibitors
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Papers overview

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2017
2017
Erratum: The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
[This corrects the article DOI: 10.1038/ncomms15751.]. 
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2012
2012
Proteasome-Dependent Disruption of the E3 Ubiquitin Ligase Anaphase-Promoting Complex by HCMV Protein pUL21a
The anaphase-promoting complex (APC) is an E3 ubiquitin ligase which controls ubiquitination and degradation of multiple cell… Expand
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Highly Cited
2012
Highly Cited
2012
Filamin A Regulates Neural Progenitor Proliferation and Cortical Size through Wee1-Dependent Cdk1 Phosphorylation
Cytoskeleton-associated proteins play key roles not only in regulating cell morphology and migration but also in proliferation… Expand
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2012
2012
Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells
Cancers that develop in BRCA1 mutation carriers are usually near tetraploid/polyploid. This led us to hypothesize that BRCA1… Expand
2010
2010
Substrate degradation by the anaphase promoting complex occurs during mitotic slippage.
Microtubule targeting drugs are successful in chemotherapy because they indefinitely activate the spindle assembly checkpoint… Expand
2010
2010
Requirements and Reasons for Effective Inhibition of the Anaphase Promoting Complex Activator Cdh1
Inhibitory phosphorylation of Cdh1 by CDK and Polo kinase has been proposed to inactivate APC-Cdh1. Through an exact gene… Expand
Review
2010
Review
2010
Tension Management in the Kinetochore
The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic… Expand
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Review
2010
Review
2010
ReviewTension Management in the Kinetochore
The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic… Expand
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2007
2007
Regulation of Gene Expression in Bovine Blastocysts in Response to Oxygen and the Iron Chelator Desferrioxamine1
Abstract Low (2%) oxygen conditions during postcompaction culture of bovine blastocysts improve embryo quality and are associated… Expand
Highly Cited
2004
Highly Cited
2004
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.
Progression through mitosis requires activation of cyclin B/Cdk1 and its downstream targets, including Polo-like kinase and the… Expand
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