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anabaseine

National Institutes of Health

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Anabasine

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anabaseine dihydrochloride
analogs & derivatives

Papers overview

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2019
2019
Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine
Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain… 
2013
2013
Interactions of acetylcholine binding site residues contributing to nicotinic acetylcholine receptor gating: role of residues Y93, Y190, K145 and D200.
2007
2007
Reversal of Agonist Selectivity by Mutations of Conserved Amino Acids in the Binding Site of Nicotinic Acetylcholine Receptors*
Homomeric α7 and heteromeric α4β2 nicotinic acetylcholine receptors (nAChR) can be distinguished by their pharmacological… 
2006
2006
Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions.
The discovery of the acetylcholine binding proteins (AChBPs) has provided critical soluble surrogates for examining structure and… 
Highly Cited
2004
Highly Cited
2004
The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors.
The alpha7 nAChR-selective partial agonist 3-(2,4-dimethoxybenzylidene)anabaseine (GTS-21) is more efficacious and potent for rat… 
2001
2001
Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor.
The nicotinic receptor drug candidate, 3-(2,4-dimethoxybenzylidene)-anabaseine (also known as GTS-21; DMXBA), its hydroxy… 
2001
2001
Amphiporus alkaloid multiplicity implies functional diversity: initial studies on crustacean pyridyl receptors
Some hoplonemertines contain pyridyl alkaloids which are used for prey capture and chemical defense against predators. The first… 
2000
2000
Inhibition of nitric oxide synthase prevents α7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus
Highly Cited
1998
Highly Cited
1998
Neuroprotective and memory-related actions of novel alpha-7 nicotinic agents with different mixed agonist/antagonist properties.
The goals of this study were to develop compounds that were selective and highly efficacious agonists at alpha-7 receptors, while… 
Review
1997
Review
1997
Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist
Naturally occurring toxins can often serve as useful chemical tools for investigating signalling processes in nervous and other… 
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