aminopyrimidine

 
National Institutes of Health

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2012
2012
A high-throughput screen against PknB, an essential serine-threonine protein kinase present in Mycobacterium tuberculosis (M… (More)
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2012
2012
Recent clinical data provided proof-of-concept for selective B-Raf inhibitors in treatment of B-Raf(V600E) mutant melanoma… (More)
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Highly Cited
2010
Highly Cited
2010
Activating alleles of Janus kinase 2 (JAK2) such as JAK2(V617F) are central to the pathogenesis of myeloproliferative neoplasms… (More)
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2010
2010
Given the significant body of data supporting an essential role for c-jun-N-terminal kinase (JNK) in neurodegenerative disorders… (More)
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2007
Highly Cited
2007
The majority of chronic phase chronic myeloid leukemia (CML) patients treated with the tyrosine kinase inhibitor (TKI) imatinib… (More)
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2006
2006
Idiopathic hypereosinophilic syndrome (HES) is a myeloproliferative disorder characterized by tissue involvement and organ… (More)
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2005
Highly Cited
2005
Resistance to or intolerance of imatinib in patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) has… (More)
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2005
2005
BACKGROUND Previous studies have shown that patients with Bcr-Abl-positive acute lymphoblastic leukemia (ALL) either have primary… (More)
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2003
Highly Cited
2003
Insulin resistance plays a central role in the development of type 2 diabetes, but the precise defects in insulin action remain… (More)
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Highly Cited
1999
Highly Cited
1999
We have developed two independent methods to measure equilibrium binding of inhibitors to membrane-bound and partially purified… (More)
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