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diaminopyrimidine

Known as: DAP 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1952-2017
05101519522016

Related topics

Related topics

3 relations

Narrower (2)

MinoxidilTrimethoprim

Broader (1)

aminopyrimidine

Related mentions per year

Related mentions per year

1953-2019
1960198020002020
diaminopyrimidine
Trimethoprim
Minoxidil
aminopyrimidine

Papers overview

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2011
2011
Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model.
BACKGROUND AND PURPOSE P2X3 and P2X2/3 receptors are highly localized on the peripheral and central pathways of nociceptive… (More)
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2009
2009
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells.
It is important to understand the regulation of stem cell division because defects in this process can cause altered tissue… (More)
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2009
2009
Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.
The purinoceptor subtypes P2X(3) and P2X(2/3) have been shown to play a pivotal role in models of various pain conditions… (More)
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2008
2008
Iclaprim, a diaminopyrimidine dihydrofolate reductase inhibitor for the potential treatment of antibiotic-resistant staphylococcal infections.
Arpida Ltd, under license from Roche AG, is developing the diaminopyrimidine dihydrofolate reductase inhibitor iclaprim for the… (More)
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2007
2007
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.
Renin is an aspartyl protease involved in the production of angiotensin II, a potent vasoconstrictor. Renin inhibitors can… (More)
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Highly Cited
2004
Highly Cited
2004
Small molecules that induce cardiomyogenesis in embryonic stem cells.
A phenotypic cell-based screen of a large combinatorial chemical library led to the identification of a class of… (More)
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2003
2003
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria.
Iclaprim, a new selective dihydrofolate inhibitor was synthesized based on rational drug design. Iclaprim's interaction with a… (More)
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1996
1996
Prebiotic synthesis of diaminopyrimidine and thiocytosine
The reaction of guanidine hydrochloride with cyanoacetaldehyde gives high yields (40–85%) of 2,4-diaminopyrimidine under the… (More)
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1994
1994
The sulfonamide-diaminopyrimidine story.
This paper is devoted to chemotherapy in the sense that Paul Ehrlich (Nobel Prize winner in 1908) coined the word: to describe… (More)
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1977
1977
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.
On the basis of activity against experimental tumors and potency as inhibitors of human dihydrofolate reductase, two compounds… (More)
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