alrestatin

Known as: 1,3-dioxo-1H-benz(de)isoquinoline-2(3H)- acetate, AY22,284 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2018
02419782018

Papers overview

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2007
2007
Angiotensin II (Ang II), a circulating hormone that can be synthesized locally in the vasculature, has been implicated in… (More)
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1997
1997
It is generally expected that only one inhibitor molecule will bind to an enzyme active site. In fact, specific drug design… (More)
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1995
1995
Human aldehyde reductase is a NADPH-dependent aldo-keto reductase that is closely related (65% identity) to aldose reductase, an… (More)
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1994
1994
Aldose reductase enfolds NADP+/NADPH via a complex loop mechanism, with cofactor exchange being the rate-limiting step for the… (More)
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1990
1990
A broad group of structurally diverse aldose reductase inhibitors including flavonoids, carboxylic acids and hydantoins, have… (More)
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1982
1982
Human brain aldose reductase and hexonate dehydrogenase are inhibited by alrestatin (AY 22,284) and sorbinil (CP 45,634… (More)
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1981
1981
The sorbitol pathway in human lenses is evaluated on the enzymic level. Adult lenses, normal and nondiabetic as well as diabetic… (More)
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1979
1979
Studies with the aldose reductase inhibitor alrestatin in animal models have suggested that the sorbitol pathway may be of… (More)
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1979
1979
Immediately after cataract extraction, lenses from diabetic and nondiabetic patients were collected, classified, and assayed or… (More)
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1978
1978
Alrestatin, a lens aldose reductase inhibitor, decreased i.v. arginine-induced glucagon levels and augmented arginine-stimulated… (More)
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