alpha7 Nicotinic Acetylcholine Receptor

Known as: nAChR alpha7 Subunit, Nicotinic Acetylcholine Receptor alpha7, alpha7nAChR 
A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric ?7 subunits… (More)
National Institutes of Health

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In Bloodagonistsantagonists & inhibitorsaspects of radiation effects
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Receptor, alpha-Bungarotoxinchrna7 protein, zebrafishnAcRalpha-7E protein, Drosophila

Papers overview

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Review
2012
Review
2012
Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology
Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover… (More)
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2009
2009
Proteomic analysis of an alpha7 nicotinic acetylcholine receptor interactome.
The alpha7 nicotinic acetylcholine receptor (nAChR) is well established as the principal high-affinity alpha-bungarotoxin-binding… (More)
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Review
2008
Review
2008
Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration
Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people worldwide. Classical studies focused… (More)
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Highly Cited
2007
Highly Cited
2007
An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.
Augmentation of nicotinic alpha7 receptor function is considered to be a potential therapeutic strategy aimed at ameliorating… (More)
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Highly Cited
2002
Highly Cited
2002
Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia.
BACKGROUND The alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) has been implicated as a candidate gene for… (More)
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Highly Cited
2001
Highly Cited
2001
Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus.
Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other… (More)
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Highly Cited
2001
Highly Cited
2001
The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.
The tryptophan metabolite kynurenic acid (KYNA) has long been recognized as an NMDA receptor antagonist. Here, interactions… (More)
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Highly Cited
2001
Highly Cited
2001
Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7).
The transmission/disequilibrium test was used for fine mapping of the linkage of schizophrenia to the chromosome 15q13-14 region… (More)
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Highly Cited
2000
Highly Cited
2000
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.
Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the loss of cholinergic neurons in the… (More)
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Highly Cited
2000
Highly Cited
2000
Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors.
We have recently reported evidence that a very high affinity interaction between the beta-amyloid peptide Abeta(1-42) and the… (More)
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