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alpha7 Nicotinic Acetylcholine Receptor

Known as: nAChR alpha7 Subunit, Nicotinic Acetylcholine Receptor alpha7, alpha7nAChR 
A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric ?7 subunits… Expand
National Institutes of Health

Related topics

Related topics

8 relations
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects
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Narrower (3)

Receptor, alpha-Bungarotoxinchrna7 protein, zebrafishnAcRalpha-7E protein, Drosophila

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Expression and Function of the Cholinergic System in Immune Cells
T and B cells express most cholinergic system components—e.g., acetylcholine (ACh), choline acetyltransferase (ChAT… Expand
Review
2010
Review
2010
Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases
In recent years the etiopathology of a number of debilitating diseases such as type 2 diabetes, arthritis, atherosclerosis… Expand
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Highly Cited
2009
Highly Cited
2009
Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.
OBJECTIVE The parasympathetic nervous system, through the vagus nerve, can down-regulate inflammation in vivo by decreasing the… Expand
Highly Cited
2009
Highly Cited
2009
Proteomic analysis of an alpha7 nicotinic acetylcholine receptor interactome.
The alpha7 nicotinic acetylcholine receptor (nAChR) is well established as the principal high-affinity alpha-bungarotoxin-binding… Expand
Highly Cited
2005
Highly Cited
2005
Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3… Expand
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Highly Cited
2002
Highly Cited
2002
Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia.
BACKGROUND The alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) has been implicated as a candidate gene for… Expand
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Highly Cited
2002
Highly Cited
2002
Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
Phenotypic modification of dorsal root ganglion (DRG) neurons represents an important mechanism underlying neuropathic pain… Expand
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Review
2002
Review
2002
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
Degradation of the essential amino acid tryptophan along the kynurenine pathway (KP) yields several neuroactive intermediates… Expand
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Highly Cited
2001
Highly Cited
2001
The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.
The tryptophan metabolite kynurenic acid (KYNA) has long been recognized as an NMDA receptor antagonist. Here, interactions… Expand
Highly Cited
2000
Highly Cited
2000
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.
Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the loss of cholinergic neurons in the… Expand
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