alpha-hydroxyglutarate

Known as: 2-HG, 2-Hydroxyglutarate 
The base form of alpha-hydroxyglutaric acid, which is an intermediate in the synthesis of alpha-ketoglutaric acid. Alpha-hydroxyglutarate accumulates… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
U niversity of California, San Francisco researchers recently reported in Science the mutational profiling of 23 initially low… (More)
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Highly Cited
2013
Highly Cited
2013
Mutations in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are common in several human cancers… (More)
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Highly Cited
2012
Highly Cited
2012
The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) mutations in… (More)
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Highly Cited
2012
Highly Cited
2012
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… (More)
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Highly Cited
2011
Highly Cited
2011
IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of… (More)
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Highly Cited
2011
Highly Cited
2011
Mutations in isocitrate dehydrogenases (IDHs) have a gain-of-function effect leading to R(-)-2-hydroxyglutarate (R-2HG… (More)
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Highly Cited
2010
Highly Cited
2010
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2… (More)
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Highly Cited
2010
Highly Cited
2010
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2), are present in most gliomas and secondary glioblastomas, but are rare in… (More)
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Highly Cited
2010
Highly Cited
2010
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production… (More)
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Highly Cited
2009
Highly Cited
2009
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain… (More)
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