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alpha-hydroxyglutarate
Known as:
2-HG
, 2-Hydroxyglutarate
The base form of alpha-hydroxyglutaric acid, which is an intermediate in the synthesis of alpha-ketoglutaric acid. Alpha-hydroxyglutarate accumulates…
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National Institutes of Health
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6 relations
2-Hydroxyglutarate:PrThr:24H:Urine:Ord
2-Hydroxyglutarate:PrThr:Pt:Urine:Ord
2-Hydroxyglutarate:SCnc:Pt:Amnio fld:Qn
Broader (2)
2-hydroxyglutaric acid
Glutarates
Narrower (1)
D-2-hydroxyglutarate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A Phase I Pharmacologic Study of Necitumumab (IMC-11F8), a Fully Human IgG1 Monoclonal Antibody
A. Bader
,
D. Brown
,
+4 authors
Scott A. Ness
2016
Corpus ID: 750244
Department of Internal Medicine and UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque…
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2014
2014
IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma
Jun Lu
,
Yang Zou
,
+5 authors
Yong-Gang Yao
Medical Science Monitor
2014
Corpus ID: 13257274
Background Recent studies have identified prevalent isocitrate dehydrogenase 1 (IDH1) codon 132 mutations (p.R132) in gliomas and…
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2012
2012
Metabolism: Unmasking an oncometabolite
N. McCarthy
Nature Reviews. Cancer
2012
Corpus ID: 29557087
Mutant IDH genes that produce 2-hydroxyglutarate can influence cell transformation through effects on DNA and histone methylation…
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2012
2012
Epigenetics: Melanoma insights written in the DNA
D. Burgess
Nature Reviews. Cancer
2012
Corpus ID: 32982239
A new study shows that disruptions to a DNA modification in melanoma may hold diagnostic and therapeutic promise.
2011
2011
Detection of 2-hydroxyglutarate in Mutant Brain Tumors in vivo using Proton Magnetic Resonance Spectroscopy
R. Nagarajan
,
M. Thomas
,
W. Pope
,
N. Wilson
,
N. Salamon
,
L. Liau
2011
Corpus ID: 99019672
Introduction: Several years ago, Frahm and co-workers reported reduced NAA, choline (Cho), creatine (Cr) and increased myo…
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2008
2008
Distribution of 14 C-IabeIled carbon from glucose and glutamate during anaerobic growth of Saccharomyces cerevisiae
Éva
,
Albers
,
L. Gustafsson
,
Claes Niklassonl
,
G. Lidén
2008
Corpus ID: 59933187
Goteborg, Sweden BOX 462, 5-40530 The distribution of carbon from glucose and glutamate was studied using anaerobically grown…
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1975
1975
Inactivation of citrate lyase from Rhodopseudomonas gelatinosa by a specific deacetylase and inhibition of this inactivation by L-(+1-glutamate
F. Giffhorn
,
G. Gottschalk
Journal of Bacteriology
1975
Corpus ID: 45872356
A previously unrecognized enzyme, citrate lyase deacetylase, has been purified about 140-fold from cell extracts of…
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1972
1972
Enzymes of the conversion of succinate to glutamate in extracts of rumen microorganisms.
B. Emmanuel
,
L. P. Milligan
Canadian Journal of Biochemistry
1972
Corpus ID: 9788922
Cell-free extracts of mixed rumen microorganisms were incubated in vitro in order to determine the existence and nature of…
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1971
1971
Purification and properties of alpha-ketoglutarate reductase from Micrococcus aerogenes.
R. Lerud
,
H. Whiteley
Journal of Bacteriology
1971
Corpus ID: 34709419
Micrococcus aerogenes grown in media containing glutamate has high levels of glutamate dehydrogenase and alpha-ketoglutarate…
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1969
1969
Alpha-hydroxyglutarate oxidoreductase of Pseudomonas putida.
M. Reitz
,
V. Rodwell
Journal of Bacteriology
1969
Corpus ID: 42488559
Oxidation of d-alpha-hydroxyglutarate to alpha-ketoglutarate is catalyzed by d-alpha-hydroxyglutarate oxidoreductase, an…
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