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alpha-hydroxyglutarate

Known as: 2-HG, 2-Hydroxyglutarate 
The base form of alpha-hydroxyglutaric acid, which is an intermediate in the synthesis of alpha-ketoglutaric acid. Alpha-hydroxyglutarate accumulates… 
National Institutes of Health

Related topics

Related topics

6 relations
2-Hydroxyglutarate:PrThr:24H:Urine:Ord2-Hydroxyglutarate:PrThr:Pt:Urine:Ord2-Hydroxyglutarate:SCnc:Pt:Amnio fld:Qn

Broader (2)

2-hydroxyglutaric acidGlutarates

Narrower (1)

D-2-hydroxyglutarate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Edited 1H magnetic resonance spectroscopy in vivo: Methods and metabolites
The Proton magnetic resonance (1H‐MRS) spectrum contains information about the concentration of tissue metabolites within a… 
Highly Cited
2014
Highly Cited
2014
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation
Isocitrate dehydrogenase 1 (IDH1), which localizes to the cytosol and peroxisomes, catalyzes the oxidative decarboxylation of… 
Highly Cited
2013
Highly Cited
2013
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma… 
Highly Cited
2013
Highly Cited
2013
Induction of sarcomas by mutant IDH2
Most chondrosarcoma patients exhibit gain-of-function mutations in either IDH1 or IDH2. Lu et al. found that IDH mutations were… 
Review
2013
Review
2013
Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes.
Highly Cited
2013
Highly Cited
2013
Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.
Highly Cited
2013
Highly Cited
2013
Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China
Significance Acute myeloid leukemia (AML) consists of a group of hematopoietic malignancies with considerable diversities in… 
Highly Cited
2012
Highly Cited
2012
Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy
2-Hydroxyglutarate, a metabolite overproduced in IDH-mutated gliomas, can be detected noninvasively in patients with brain tumors… 
Highly Cited
2012
Highly Cited
2012
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia.
Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical… 
Highly Cited
2012
Highly Cited
2012
Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)*
Background: Isocitrate dehydrogenase (IDH) mutations occur in diverse tumor types, leading to production of the oncometabolite 2… 
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