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alpha-hydroxyglutarate

Known as: 2-HG, 2-Hydroxyglutarate 
The base form of alpha-hydroxyglutaric acid, which is an intermediate in the synthesis of alpha-ketoglutaric acid. Alpha-hydroxyglutarate accumulates… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Metabolic reprogramming has become a key focus for both immunologists and cancer biologists, with exciting advances providing new… Expand
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Review
2019
Review
2019
Background Cancer cells possess a common metabolic phenotype, rewiring their metabolic pathways from mitochondrial oxidative… Expand
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Review
2017
Review
2017
The Proton magnetic resonance (1H‐MRS) spectrum contains information about the concentration of tissue metabolites within a… Expand
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Highly Cited
2012
Highly Cited
2012
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… Expand
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Highly Cited
2012
Highly Cited
2012
The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) mutations in… Expand
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Highly Cited
2011
Highly Cited
2011
IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of… Expand
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Highly Cited
2011
Highly Cited
2011
Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis… Expand
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Highly Cited
2010
Highly Cited
2010
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2… Expand
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Highly Cited
2010
Highly Cited
2010
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production… Expand
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Highly Cited
2009
Highly Cited
2009
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain… Expand
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