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D-2-hydroxyglutarate

National Institutes of Health

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Broader (1)

alpha-hydroxyglutarate

Papers overview

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2018
2018
D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant–Induced MIR148A Promoter Methylation
Mutant isocitrate dehydrogenase (IDH) 1/2 converts α-ketoglutarate (α-KG) to D-2 hydroxyglutarate (D-2-HG), a putative… 
2017
2017
Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1.
2016
2016
Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis
The prevalence of mutant isocitrate dehydrogenase 1 (IDH1) brain tumors has generated significant efforts to understand the role… 
2016
2016
A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model
D-2-hydroxyglutaric aciduria (D2HGA) type II is a rare neurometabolic disorder caused by germline gain-of-function mutations in… 
2015
2015
A high-sensitive HMab-2 specifically detects IDH1-R132H, the most common IDH mutation in gliomas.
2013
2013
Reply to Struys: Role of biomarker of 2-hydroxyglutarate in acute myeloid leukemia
We agree with E. A. Struys’ point (1) that 2-hydroxyglutarate (2-HG) consists of two distinct forms, l-2-hydroxyglutarate (L2HG… 
2009
2009
Measurement of d-2-hydroxyglutarate dehydrogenase activity in cell homogenates derived from d-2-hydroxyglutaric aciduria patients
Summaryd-2-Hydroxyglutaric aciduria (d-2-HGA) is a neurometabolic disorder characterized by elevated levels of d-2… 
2004
2004
Investigations by mass isotopomer analysis of the formation of D‐2‐hydroxyglutarate by cultured lymphoblasts from two patients with D‐2‐hydroxyglutaric aciduria
2003
2003
Disease-related metabolites in culture medium of fibroblasts from patients with D-2-hydroxyglutaric aciduria, L-2-hydroxyglutaric aciduria, and combined D/L-2-hydroxyglutaric aciduria.
BACKGROUND D-2-Hydroxyglutaric aciduria (D-2-HGA), L-2-hydroxyglutaric aciduria (L-2-HGA), and the combined D/L-2-hydroxyglutaric… 
2000
2000
Cloning and characterization of a putative human d-2-hydroxyacid dehydrogenase in chromosome 9q.
There is little information on d-isomer-specific dehydrogenases in humans. Identification of d-2-hydroxyglutaric aciduria, an… 
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