D-2-hydroxyglutarate

 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Somatic mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) contribute to the pathogenesis of cancer via production of the… (More)
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2014
2014
Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified… (More)
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2014
2014
Mutations in the cytosolic NADP(+)-dependent isocitrate dehydrogenase (IDH1) occur in several types of cancer, and altered… (More)
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Highly Cited
2013
Highly Cited
2013
Point mutations at Arg132 of the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) occur frequently in gliomas and… (More)
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Highly Cited
2012
Highly Cited
2012
Isocitrate dehydrogenase-1 (IDH1) R132 mutations occur in glioma, but their physiological significance is unknown. Here we… (More)
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Highly Cited
2012
Highly Cited
2012
Recent studies have indicated that a significant survival advantage is conferred to patients with gliomas whose lesions harbor… (More)
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Highly Cited
2010
Highly Cited
2010
Heterozygous somatic mutations in the genes encoding isocitrate dehydrogenase-1 and -2 (IDH1 and IDH2) were recently discovered… (More)
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2006
2006
gamma-Hydroxybutyratic acid (GHB), and its prodrugs 4-butyrolactone and 1,4-butanediol, represent expanding drugs of abuse… (More)
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Highly Cited
2005
Highly Cited
2005
d-2-hydroxyglutaric aciduria is a neurometabolic disorder with both a mild and a severe phenotype and with unknown etiology… (More)
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2004
2004
Extracts of frozen rat liver were found to catalyse the formation of 3H2O from DL-2-hydroxy[2-3H]glutarate. Three peaks of enzyme… (More)
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