D-2-hydroxyglutarate
National Institutes of Health
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The prevalence of mutant isocitrate dehydrogenase 1 (IDH1) brain tumors has generated significant efforts to understand the role…
A single amino acid substitution, R140Q, in isocitrate dehydrogenase 2 (IDH2) confers a novel enzymatic activity that converts…
BACKGROUND: IDH1R132H mutations are both inaugural events in the formation of glioma and associated with prolonged glioma patient…
The compound 2-hydroxyglutarate (2-HG; Figure 1) is normally present at low levels in cells and is interconverted to alpha…
Background: The mutations of cytosolic isocitrate dehydrogenase 1 and 2 enzymes (IDH1 and IDH2) are a common occurrence in…
The 2-position substituent on substrates or substrate analogues for glutamate dehydrogenase is shown to be intimately involved in…