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alfimeprase

Known as: 3-203-Fibrolase (3-serine) (Agkistrodon contortrix contortrix recombinant) 
 
National Institutes of Health

Papers overview

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2010
2010
PURPOSE To investigate the safety and effectiveness of a novel thrombolytic, alfimeprase, in catheter-directed thrombolysis (CDT… Expand
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Review
2010
Review
2010
Fibrolase is the fibrinolytic enzyme isolated from Agkistrodon contortrix contortrix (southern copperhead snake) venom. The… Expand
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2009
2009
OBJECTIVE Recanalization therapies for ischemic stroke have been slow to change clinical practice because of perceived and… Expand
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2007
2007
Alfimeprase is an analog of a fibrolase that disrupts formed thrombi through the hydrolysis of fibrin, rather than by activation… Expand
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2007
2007
Alfimeprase (ALF) is a truncated form of non-hemorrhagic zinc metalloproteinase fibrolase. In order to achieve a high level… Expand
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2006
2006
PURPOSE Alfimeprase is a recombinantly produced, genetically modified variant of the metalloproteinase, fibrolase. Alfimeprase… Expand
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Review
2006
Review
2006
Alfimeprase is a recombinant, direct-acting fibrinolytic zinc metalloprotease. Alfimeprase has direct proteolytic activity… Expand
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2005
2005
PURPOSE To evaluate the safety profile, pharmacokinetics, and thrombolytic activity of alfimeprase, a novel direct-acting… Expand
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2001
2001
The disulfide structure of alfimeprase, a recombinant analog of fibrolase, was experimentally determined by a combination of… Expand
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2000
2000
We report the results of a multidisciplinary study on the inhibitory effect of a snake venom disintegrin, contortrostatin, a 13.5… Expand
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