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alfimeprase

Known as: 3-203-Fibrolase (3-serine) (Agkistrodon contortrix contortrix recombinant) 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Metalloendopeptidases

Papers overview

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2013
2013
Hirudin and S18886 Maintain Luminal Patency After Thrombolysis With Alfimeprase
Background: An optimal strategy to improve reperfusion in patients with arterial occlusions is a recognized clinical need. We… 
2009
2009
Hemorrhagic profile of the fibrinolytic alfimeprase after ischemia and reperfusion
Abstract Objective: Recanalization therapies for ischemic stroke have been slow to change clinical practice because of perceived… 
Review
2008
Review
2008
Alfimeprase for the treatment of acute peripheral arterial occlusion
Background: Catheter-directed thrombolysis for the management of acute peripheral arterial occlusion emerged as a viable… 
2007
2007
Drug evaluation: alfimeprase, a plasminogen-independent thrombolytic.
Alfimeprase is an analog of a fibrolase that disrupts formed thrombi through the hydrolysis of fibrin, rather than by activation… 
2007
2007
Alfimeprase, a plasminogen-independent thrombolytic
2007
2007
Expression, purification, and activity identification of Alfimeprase in Pichia pastoris.
2006
2006
Soluble Expression and Purification of Snake Venoms Fihrino(geno)lytic Emzyme Alfimeprase in E.coli
Fibrolase is a non-hemorrhagic zinc metalloproteinase isolated from southern copperhead snake venom (Agkistrodon contortrix… 
2005
2005
A phase I trial of alfimeprase for peripheral arterial thrombolysis.
PURPOSE To evaluate the safety profile, pharmacokinetics, and thrombolytic activity of alfimeprase, a novel direct-acting… 
2004
2004
Safety and Efficacy of Alfimeprase for Restoring Function in Occluded Central Venous Catheters: Interim Results of a Phase 2, Multicenter, Randomized, Double-Blind Study (NuCath).
Alfimeprase, a recombinantly produced 22.6 kilodalton metalloproteinase, is a genetically modified variant of fibrolase… 
2001
2001
Disulfide structure of alfimeprase: A recombinant analog of fibrolase
The disulfide structure of alfimeprase, a recombinant analog of fibrolase, was experimentally determined by a combination of… 
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