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alanosine

Known as: L-Alanosine, L-2-amino-3-(N-nitroso)hydroxylaminopropionic acid, 3-(Hydroxynitrosoamino)-L-alanine 
An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

AlanineAntibiotics, AntineoplasticChelating Agents

Narrower (2)

NSC 153,353SDX 102
analogs & derivatives

Papers overview

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Highly Cited
2009
Highly Cited
2009
A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer
SummaryObjective: Methylthioadenosine phosphorylase (MTAP)–deficient tumors are dependent on the de novo purine synthesis pathway… 
Highly Cited
1999
Highly Cited
1999
Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro.
Methylthioadenosine phosphorylase (MTAP) is an important enzyme for the salvage of adenine and methionine and is deficient in a… 
Highly Cited
1996
Highly Cited
1996
Rat C6 and human astrocytic tumor cells express a neuronal type of glutamate transporter.
Highly Cited
1988
Highly Cited
1988
Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.
1988
1988
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell…
SummaryOne hundred and forty-four evaluable patients with recurrent or metastatic renal cell carcinoma (RCC) were treated with… 
1984
1984
Differential effects of inhibitors of purine metabolism on two trichomonad species.
1981
1981
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity.
1976
1976
Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine monophosphate.
2-Amino-3-(hydroxynitrosoamino)propionic acid (alanosine), at a concentration as low as 2.7 muM, completely inhibits the… 
1975
1975
Genetic analysis of the cell surface: association of human chromosome 5 with sensitivity to diphtheria toxin in mouse-human somatic cell hybrids.
Diphtheria toxin inhibits protein synthesis in eukaryotic cells by catalyzing inactivation of elongation factor 2. The 10,000… 
Highly Cited
1966
Highly Cited
1966
Alanosine, a New Antiviral and Antitumour Agent isolated from a Streptomyces
DURING the course of a systematic screening for antibiotics with antiviral activity, Streptomyces alanosinicus nov. sp. (ATCC… 
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