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alanine-tRNA ligase activity

Known as: alanyl-transfer ribonucleic acid synthetase activity, alanyl-transfer ribonucleate synthase activity, alanine transfer RNA synthetase activity 
Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). [EC:6.1.1.7]
National Institutes of Health

Papers overview

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2014
2014
Relaxed Substrate Specificity Leads to Extensive tRNA Mischarging by Streptococcus pneumoniae Class I and Class II Aminoacyl-tRNA Synthetases
ABSTRACT Aminoacyl-tRNA synthetases provide the first step in protein synthesis quality control by discriminating cognate from… 
2006
2006
Molecular biology: Sticky end in protein synthesis
It's not clear what general level of accuracy is required in translating the genetic code. But the protective role of proof… 
2002
2002
Efficient aminoacylation of the tRNA(Ala) acceptor stem: dependence on the 2:71 base pair.
Specific aminoacylation by aminoacyl-tRNA synthetases requires accurate recognition of cognate tRNA substrates. In the case of… 
Highly Cited
1998
Highly Cited
1998
A new assay for tRNA aminoacylation kinetics.
An improved quantitative assay for tRNA aminoacylation is presented based on charging of a nicked tRNA followed by separation of… 
1996
1996
Specific function of a G.U wobble pair from an adjacent helical site in tRNA(Ala) during recognition by alanyl-tRNA synthetase.
G.U wobble pairs are crucial to many examples of RNA-protein recognition. We previously concluded that the G.U wobble pair in the… 
1995
1995
Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase.
The class-defining active site domain of the 10 class II tRNA synthetases is well conserved and, based on the crystal structure… 
1994
1994
The invariant arginine in motif 2 of Escherichia coli alanyl-tRNA synthetase is important for catalysis but not for substrate binding.
Structural motifs 2 and 3, located in the active site of class II aminoacyl-tRNA synthetases, each contain an invariant arginine… 
1993
1993
Amino acid substitutions at position 73 in motif 2 of Escherichia coli alanyl-tRNA synthetase.
Lysine73, located in the adenylate synthesis domain of Escherichia coli alanyl-tRNA synthetase (AlaRS), was previously indicated… 
Highly Cited
1991
Highly Cited
1991
A model of the alar ligaments of the upper cervical spine in axial rotation.
1962
1962
EFFECTS OF REDUCED OXYGEN TENSION ON VASCULAR PLANTS, IV. WINTER RYE GERMINATION UNDER NEAR-MARTIAN CONDITIONS AND IN OTHER NONTERRESTRIAL ENVIRONMENTS.
The existence of life under nonterrestrial conditions has been a subject of extended literary and scientific interest. Astronomy… 
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