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alanine-tRNA ligase activity
Known as:
alanyl-transfer ribonucleic acid synthetase activity
, alanyl-transfer ribonucleate synthase activity
, alanine transfer RNA synthetase activity
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Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). [EC:6.1.1.7]
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Relaxed Substrate Specificity Leads to Extensive tRNA Mischarging by Streptococcus pneumoniae Class I and Class II Aminoacyl-tRNA Synthetases
J. Shepherd
,
M. Ibba
mBio
2014
Corpus ID: 18741792
ABSTRACT Aminoacyl-tRNA synthetases provide the first step in protein synthesis quality control by discriminating cognate from…
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2006
2006
Molecular biology: Sticky end in protein synthesis
H. Roy
,
M. Ibba
Nature
2006
Corpus ID: 5998660
It's not clear what general level of accuracy is required in translating the genetic code. But the protective role of proof…
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2002
2002
Efficient aminoacylation of the tRNA(Ala) acceptor stem: dependence on the 2:71 base pair.
P. Beuning
,
Maria C. Nagan
,
C. Cramer
,
K. Musier-Forsyth
,
J. Gelpí
,
D. Bashford
RNA: A publication of the RNA Society
2002
Corpus ID: 23688795
Specific aminoacylation by aminoacyl-tRNA synthetases requires accurate recognition of cognate tRNA substrates. In the case of…
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Highly Cited
1998
Highly Cited
1998
A new assay for tRNA aminoacylation kinetics.
A. Wolfson
,
J. Pleiss
,
O. Uhlenbeck
RNA: A publication of the RNA Society
1998
Corpus ID: 20027270
An improved quantitative assay for tRNA aminoacylation is presented based on charging of a nicked tRNA followed by separation of…
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1996
1996
Specific function of a G.U wobble pair from an adjacent helical site in tRNA(Ala) during recognition by alanyl-tRNA synthetase.
W. McClain
,
K. Gabriel
,
J. Schneider
RNA: A publication of the RNA Society
1996
Corpus ID: 25328619
G.U wobble pairs are crucial to many examples of RNA-protein recognition. We previously concluded that the G.U wobble pair in the…
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1995
1995
Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase.
D. Buechter
,
P. Schimmel
Biochemistry
1995
Corpus ID: 5939972
The class-defining active site domain of the 10 class II tRNA synthetases is well conserved and, based on the crystal structure…
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1994
1994
The invariant arginine in motif 2 of Escherichia coli alanyl-tRNA synthetase is important for catalysis but not for substrate binding.
Y. Lu
,
K. Hill
Journal of Biological Chemistry
1994
Corpus ID: 30391339
Structural motifs 2 and 3, located in the active site of class II aminoacyl-tRNA synthetases, each contain an invariant arginine…
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1993
1993
Amino acid substitutions at position 73 in motif 2 of Escherichia coli alanyl-tRNA synthetase.
S. Filley
,
Kelvin Hill
Archives of Biochemistry and Biophysics
1993
Corpus ID: 23312331
Lysine73, located in the adenylate synthesis domain of Escherichia coli alanyl-tRNA synthetase (AlaRS), was previously indicated…
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Highly Cited
1991
Highly Cited
1991
A model of the alar ligaments of the upper cervical spine in axial rotation.
J. Crisco
,
M. Panjabi
,
J. Dvořák
Journal of Biomechanics
1991
Corpus ID: 28680207
1962
1962
EFFECTS OF REDUCED OXYGEN TENSION ON VASCULAR PLANTS, IV. WINTER RYE GERMINATION UNDER NEAR-MARTIAN CONDITIONS AND IN OTHER NONTERRESTRIAL ENVIRONMENTS.
S. Siegel
,
L. Rosen
,
C. Giumarro
Proceedings of the National Academy of Sciences…
1962
Corpus ID: 7497277
The existence of life under nonterrestrial conditions has been a subject of extended literary and scientific interest. Astronomy…
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