aggrecanase

Known as: NITEGE 
 
National Institutes of Health

Papers overview

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2014
2014
OBJECTIVE Wnt signaling is a master regulator of joint homeostasis, but its role in osteoarthritis (OA) remains unclear. This… (More)
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2012
2012
Sox9 is an essential transcription factor for the differentiation of the chondrocytic lineage during embryonic development. To… (More)
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2011
2011
OBJECTIVE To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase… (More)
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2009
2009
Several inhibitors of a series of cis-1(S)2(R)-amino-2-indanol-based compounds were reported to be selective for the aggrecanases… (More)
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Highly Cited
2008
Highly Cited
2008
INTRODUCTION Physiological and pathophysiological cartilage turnover may coexist in articular cartilage. The distinct enzymatic… (More)
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2004
2004
OBJECTIVE Aggrecan is degraded by Aggrecanases (ADAMTS-4 and -5) and MMPs, which cleave its core protein at different sites… (More)
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2003
2003
OBJECTIVE To study the production of aggrecanase 1 (ADAM-TS4) in monolayer chondrocytes, capsular fibroblasts, and cartilage… (More)
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1999
1999
OBJECTIVE Two major cleavage sites, one mediated by metalloproteinases (MMPs) and the other by an as-yet unidentified enzyme… (More)
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1999
1999
Erosion of cartilage is a major feature of joint diseases, i.e., osteoarthritis and rheumatoid arthritis, which leads with time… (More)
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Highly Cited
1998
Highly Cited
1998
A rat chondrosarcoma cell line and bovine cartilage explants have been used to study the control of aggrecan degradation by… (More)
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