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aggrecanase

Known as: NITEGE 
National Institutes of Health

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Broader (1)

Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Effects of stimulated aggrecanolysis on nanoscale morphological and mechanical properties of wild-type and aggrecanase-resistant mutant mice cartilages
A key event in arthritis pathogenesis is the degradation of aggrecan, the major component in articular cartilage. In this work… 
2017
2017
04.04 Suramin protects against osteoarthritis by increasing tissue inhibitor of matrix metalloproteinase-3 and glycosaminoglycans in the articular cartilage
Purpose Drug repositioning is a recent pharmaceutical strategy to discover new uses for market-approved drugs, with known safety… 
2015
2015
SAT0038 Osteoclasts Activate Chondrocyte Catabolism Through S1P Production
Background Subchondral bone features accompanied all stages development of osteoarthritis (OA). We have previously demonstrated… 
2015
2015
AB0832 Serum Levels of Aggrecan Args, Nitege Fragments in Tunisian Patients with Knee Osteoarthritis: Clinical, and Radiological Correlation
Background Proteolytic degradation of aggrecan is a hallmark of the pathology of osteoarthritis. In this study, we analyzed the… 
2011
2011
NITEGE-Expression in Meniscal Matrix. A New, Immunohistochemical Marker of Meniscal-Tissue Degeneration
Background: No marker reflecting the pathobiology of meniscal degeneration (MD) is established so far. NITEGE is a hexapeptide… 
2010
2010
Histopathologischer Degenerations-Score des Faserknorpels
ZusammenfassungObwohl die histopathologische Diagnostik der Meniskusdegeneration eine wichtige Rolle spielt, gibt es keine… 
Highly Cited
2000
Highly Cited
2000
Age-related Changes in Aggrecan Glycosylation Affect Cleavage by Aggrecanase*
Aggrecan degradation involves proteolytic cleavage of the core protein within the interglobular domain. Because aggrecan is… 
2000
2000
Mannosamine inhibits aggrecanase-mediated degradation of the mechanically functional portion of proteoglycans and of the physical properties of articular cartilage
The enzymatic processes underlying the degradation of aggrecan in cartilage and the corresponding changes in the biomechanical… 
Highly Cited
1999
Highly Cited
1999
Identification of aggrecanase activity in medium of cartilage culture.
Erosion of cartilage is a major feature of joint diseases, i.e., osteoarthritis and rheumatoid arthritis, which leads with time… 
1998
1998
The Interglobular Domain of Cartilage Aggrecan Is Cleaved by Hemorrhagic Metalloproteinase HT-d (Atrolysin C) at the Matrix Metalloproteinase and Aggrecanase Sites*
Two primary cleavage sites have been identified within the interglobular domain of the cartilage aggrecan core protein: one is… 
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