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aggrecanase

Known as: NITEGE 
National Institutes of Health

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Broader (1)

Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Histopathologischer Degenerations-Score des Faserknorpels
ZusammenfassungObwohl die histopathologische Diagnostik der Meniskusdegeneration eine wichtige Rolle spielt, gibt es keine… 
2009
2009
Roles of metalloproteinase-3 and aggrecanase 1 and 2 in aggrecan cleavage during human meniscus degeneration
The meniscus plays important roles in proper knee function. It was recently reported that meniscus degeneration was associated… 
2007
2007
Development and characterization of a novel ELISA based assay for the quantitation of sub-nanomolar levels of neoepitope exposed NITEGE-containing aggrecan fragments.
2004
2004
3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase.
N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase… 
2002
2002
Potent P1' biphenylmethyl substituted aggrecanase inhibitors.
Highly Cited
2001
Highly Cited
2001
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable…
A pharmacophore model of the P1' site, specific for aggrecanase, was defined using the specificity studies of the matrix… 
Highly Cited
2000
Highly Cited
2000
Age-related Changes in Aggrecan Glycosylation Affect Cleavage by Aggrecanase*
Aggrecan degradation involves proteolytic cleavage of the core protein within the interglobular domain. Because aggrecan is… 
Highly Cited
1999
Highly Cited
1999
Identification of aggrecanase activity in medium of cartilage culture.
Erosion of cartilage is a major feature of joint diseases, i.e., osteoarthritis and rheumatoid arthritis, which leads with time… 
1998
1998
The Interglobular Domain of Cartilage Aggrecan Is Cleaved by Hemorrhagic Metalloproteinase HT-d (Atrolysin C) at the Matrix Metalloproteinase and Aggrecanase Sites*
Two primary cleavage sites have been identified within the interglobular domain of the cartilage aggrecan core protein: one is… 
Highly Cited
1995
Highly Cited
1995
Cell-mediated Catabolism of Aggrecan
A rat chondrosarcoma cell line and primary bovine chondrocytes have been used to study cell-mediated aggrecan catabolism… 
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