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Minocycline selectively inhibits M1 polarization of microglia
TLDR
It is indicated that minocycline selectively inhibits the microglia polarization to a proinflammatory state, and provides a basis for understanding pathogeneses of many diseases accompanied by microglial activation. Expand
A MULTICENTRE STUDY
TLDR
It may be that early foraminotomy in susceptible individuals and the avoidance of tethering of the cord by excessive laminoplasty may prevent a post-operative palsy of the C5 nerve root. Expand
Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms.
TLDR
It is reported that transplantation of human dental pulp stem cells into the completely transected adult rat spinal cord resulted in marked recovery of hind limb locomotor functions and that tooth-derived stem cells may provide therapeutic benefits for treating SCI through both cell-autonomous and paracrine neuroregenerative activities. Expand
Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis
TLDR
This postmarketing surveillance study of patients treated with infliximab showed that inflixIMab in combination with low-dose MTX was well tolerated in Japanese patients with active RA. Expand
MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas.
TLDR
The MR features described in this study are useful for distinguishing malignant peripheral nerve sheath tumors from neurofibromas and should be subjected to a biopsy for early diagnosis. Expand
Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis--a preliminary result of three cases.
TLDR
Although these results are still preliminary, transplantation of osteoblast-like cells and PRP, which seemed to be a safe and minimally invasive cell therapy, could shorten the treatment period by acceleration of bone regeneration during distraction osteogenesis. Expand
Depression, inflammation, and pain in patients with rheumatoid arthritis.
TLDR
Depression severity and inflammation were associated with each other and appeared to have independent effects on perceived pain, suggesting a clinical approach that takes into account both the body and the mind could have benefits and could enable optimal pain control. Expand
Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.
TLDR
Six genes including cyclin D1, cathepsin B, cofilin, ring finger protein 11 (RNF11), integrin-alpha6, and stanniocalcin 1 (STC1) genes were also induced in TGW human neuroblastoma cells in response to glial cell line-derived neurotrophic factor stimulation. Expand
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury
TLDR
The data suggest that the core protein in a proteoglycan moiety is also important for the inhibition of neural plasticity, and provides a potentially safer tool for the treatment of neuronal injuries. Expand
The effect of the platelet concentration in platelet-rich plasma gel on the regeneration of bone.
TLDR
It is indicated that a high platelet concentration in the platelet-rich plasma in combination with osteoblastic cells could accelerate the formation of new bone during limb-lengthening procedures. Expand
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