adozelesin

Known as: (7bR,8aS)-N-(2-((4,5,8,8a-Tetrahydro-7-methyl-4-oxocyclopropa(c)pyrrolo(3,2-e)indol-2(1H)-yl)carbonyl)indol-5-yl)-2-benzofurancarboxamide, 6-(3-methoxy-1-methyl-3-oxo-1-propenyl)-3-methyl-2-cyclohexene-1-carboxylic acid methyl ester 
An alkylating agent that bind to the DNA minor groove in a sequence-specific manner and form covalent adducts with adenines, resulting in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2010
024619912010

Papers overview

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2000
2000
The cyclopropylpyrroloindole anti-cancer drug, adozelesin, binds to and alkylates DNA. Treatment of human cells with low levels… (More)
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1999
1999
DNA damaging agents induce a conserved intra-S-phase checkpoint that inhibits DNA replication in eukaryotic cells. To better… (More)
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1998
1998
Adozelesin is the first of a class of DNA-sequence-selective alkylating agents, the cyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-ones… (More)
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1998
1998
Adozelesin and carzelesin are synthetic analogues of the extremely potent antitumor antibiotic CC-1065, which alkylates N3 of… (More)
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1997
1997
Adozelesin, a synthetic analog of the antitumor antibiotic CC-1065, is a novel cytotoxic agent which inhibits DNA synthesis by… (More)
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1994
1994
BACKGROUND Adozelesin, a synthetic analogue of the antitumor antibiotic CC-1065, is the first of a class of potent sequence… (More)
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1994
1994
During a phase I clinical and pharmacologic trial, 26 patients with refractory solid tumors were treated with increasing doses of… (More)
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1992
1992
Adozelesin (U-73975) was highly cytotoxic to V79 cells in culture and was more cytotoxic than several clinically active antitumor… (More)
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1992
1992
Adozelesin (U-73975) is an extremely potent cytotoxic agent which causes 90% lethality, after 2 h exposure in vitro, of Chinese… (More)
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1991
1991
Adozelesin (U-73975) is a potent synthetic cyclopropylpyrroloindole (CPI) analog of the cytotoxic DNA-binding antibiotic, CC-1065… (More)
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