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adozelesin

Known as: (7bR,8aS)-N-(2-((4,5,8,8a-Tetrahydro-7-methyl-4-oxocyclopropa(c)pyrrolo(3,2-e)indol-2(1H)-yl)carbonyl)indol-5-yl)-2-benzofurancarboxamide, 6-(3-methoxy-1-methyl-3-oxo-1-propenyl)-3-methyl-2-cyclohexene-1-carboxylic acid methyl ester 
An alkylating agent that bind to the DNA minor groove in a sequence-specific manner and form covalent adducts with adenines, resulting in the… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Antineoplastic Agents, AlkylatingCyclohexanecarboxylic AcidsCyclohexenesIndoles

Narrower (1)

U 73975

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.
One achiral seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) (12) and seven achiral seco-amino-CBI (11a-g) analogues of CC-1065… 
2004
2004
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
2003
2003
Induction of DNA damage responses by adozelesin is S phase-specific and dependent on active replication forks.
Adozelesin is an alkylating minor groove DNA binder that is capable of rapidly inhibiting DNA replication in treated cells… 
2002
2002
Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f…
1997
1997
Synthesis, cytotoxicity, antitumor activity and sequence selective binding of two pyrazole analogs structurally related to the antitumor agents U-71,184 and adozelesin.
Two pyrazole analogs structurally related to the antitumor agents adozelesin and U-71,184 respectively were synthesized. By using… 
Review
1997
Review
1997
DNA minor groove binding ligands: a new class of anticancer agents.
This paper gives an overview of the available pharmacological and clinical data of a new class of anticancer drugs which act by… 
1994
1994
Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits.
1,2-Dihydro-1-(chloromethyl)-5-hydroxy-8-methyl-3H-furano[3,2-e]in dole (CFI) as a novel replacement of the… 
1993
1993
In vivo mutagenesis induced by CC-1065 and adozelesin DNA alkylation in a transgenic mouse model.
Although considerable work has focused on characterizing the bonding chemistry and sequence selective alkylation of DNA by… 
1992
1992
Reversibility of the covalent reaction of CC-1065 and analogues with DNA.
Covalent DNA adducts of the antitumor antibiotic CC-1065 and its analogues undergo a retrohomologous Michael reaction in aqueous… 
1991
1991
In vitro and in vivo DNA bonding by the CC-1065 analogue U-73975.
CC-1065, a cyclopropylpyrroloindole (CPI), is a highly potent antitumor DNA-alkylating agent. We have devised a simple method to… 
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